The limited number of available nucleotide and protein sequence data from the recent H7N9 cases in China impeded investigation and characterization of the outbreak

Dear Editor,Nucleotide and protein sequences of isolates collected from infected populations can be useful for determining the threats,such as host adaptation,which are associated with the emergence of new lineages.March 2013 saw the first reports of a new H7N9 lineage in Shanghai,China that saw a g...

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Bibliographic Details
Published in:Virologica Sinica 2014-04, Vol.29 (2), p.126-127
Main Authors: Liu, Haizhou, Han, Na, Fang, Wei, Adams, James, Zheng, Kou, Li, Tianxian, Hu, Zhihong, Rayner, Simon
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
China - epidemiology
Disease Outbreaks
Evolution, Molecular
Humans
Influenza A Virus, H7N9 Subtype - classification
Influenza A Virus, H7N9 Subtype - genetics
Influenza, Human - epidemiology
Influenza, Human - virology
Letter
Medical Microbiology
Microbial Genetics and Genomics
Microbiology
Molecular Epidemiology
Oncology
RNA, Viral - genetics
Sequence Analysis, DNA
Viral Proteins - genetics
Virology
Zoonoses - epidemiology
Zoonoses - virology
上市
中国
序列数据
核苷酸
爆发
病例
蛋白质序列
鉴定
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Summary:Dear Editor,Nucleotide and protein sequences of isolates collected from infected populations can be useful for determining the threats,such as host adaptation,which are associated with the emergence of new lineages.March 2013 saw the first reports of a new H7N9 lineage in Shanghai,China that saw a gradual increase in the number of cases;but,by 17th May 2013,four Chinese provinces had ended their emergency response to H7N9 bird flu.However,despite detailed reports on human cases,the publicly available sequences from collected isolates were relatively few.By analyzing the data at this time we show that limited insight can be obtained from a relatively small dataset and,in particular,more avian isolates are necessary to consider host adaption.With reports of new H7N9 cases in South China our findings are relevant to establishing effective monitoring and determining the risk associated with these new events.
ISSN:1674-0769
1995-820X
DOI:10.1007/s12250-014-3394-1