VEGF Immunoexpression in Prostate Adenocarcinoma

Angiogenesis is a basic biomolecular mechanism for tumor progression, the vascular endothelial growth factor (VEGF) being one of the main enhancers of this complex process. In this study, we analyzed VEGF-A immunoexpression in 61 prostate adenocarcinomas (PAs), related to the prognostic parameters o...

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Bibliographic Details
Published in:Current health sciences journal 2021-01, Vol.47 (1), p.89-95
Main Authors: Pănuş, Andrei, Simionescu, Cristiana Eugenia, Drăgoescu, Petru Octavian, Stepan, Alex Emilian
Format: Article
Language:English
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Summary:Angiogenesis is a basic biomolecular mechanism for tumor progression, the vascular endothelial growth factor (VEGF) being one of the main enhancers of this complex process. In this study, we analyzed VEGF-A immunoexpression in 61 prostate adenocarcinomas (PAs), related to the prognostic parameters of the lesions. VEGF scores were higher in PAs that associated serum PSA values above 20ng/ml, in tumors with pure complex or mixed growth patterns, as well as in high-grade and advanced lesions. The results obtained indicate the involvement of VEGF in prostate angiogenesis and the usefulness of the maker for the identification of aggressive lesions.
ISSN:2067-0656
2069-4032
DOI:10.12865/CHSJ.47.01.14