Characterization of a recombinant Akabane mutant virus with knockout of a nonstructural protein NSs in a pregnant goat model

Dear Editor,Akabane virus（AKAV）,an orthobunyavirus,is transmitted primarily by biting midges and is widely distributed throughout the world except the Europe.AKAV was first isolated from mosquitoes in Japan（Oya et al.,1961）.Although pregnant cows,ewes,and goats infected with AKAV exhibit no clinical...

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Bibliographic Details
Published in:Virologica Sinica 2016-06, Vol.31 (3), p.274-277
Main Authors: Takenaka-Uema, Akiko, Bangphoomi, Norasuthi, Shioda, Chieko, Uchida, Kazuyuki, Gen, Fumihiro, Kato, Kentaro, Haga, Takeshi, Murakami, Shin, Akashi, Hiroomi, Hoimoto, Taisuke
Format: Article
Language:English
Subjects:
Animals
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Antigens, Viral - blood
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bunyaviridae Infections - immunology
Bunyaviridae Infections - prevention & control
Bunyaviridae Infections - veterinary
Bunyaviridae Infections - virology
Female
Gene Knockout Techniques
Goat Diseases - immunology
Goat Diseases - prevention & control
Goat Diseases - virology
Goats
Letter
Medical Microbiology
Microbial Genetics and Genomics
Microbiology
NSS
Oncology
Orthobunyavirus - genetics
Orthobunyavirus - immunology
Pregnancy
Pregnancy Complications, Infectious - immunology
Pregnancy Complications, Infectious - prevention & control
Pregnancy Complications, Infectious - veterinary
Pregnancy Complications, Infectious - virology
RNA, Viral - blood
RNA, Viral - genetics
Vaccines, Attenuated - immunology
Vaccines, Attenuated - pharmacology
Viral Nonstructural Proteins - genetics
Viral Nonstructural Proteins - immunology
Viral Vaccines - immunology
Viral Vaccines - pharmacology
Virology
基因敲除
山羊
怀孕
病毒特性
突变体
重组
非结构蛋白
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Summary:Dear Editor,Akabane virus（AKAV）,an orthobunyavirus,is transmitted primarily by biting midges and is widely distributed throughout the world except the Europe.AKAV was first isolated from mosquitoes in Japan（Oya et al.,1961）.Although pregnant cows,ewes,and goats infected with AKAV exhibit no clinical signs of disease,in utero infections result in abortion,premature birth,stillbirth,
ISSN:1674-0769
1995-820X
DOI:10.1007/s12250-015-3704-2