Risk factors for hydroxychloroquine retinopathy in systemic lupus erythematosus: a case–control study with hydroxychloroquine blood-level analysis

Abstract Objective HCQ is an essential medication in SLE, proven to lengthen survival and reduce flares. Its use, however, is limited by its rare but severe ophthalmological complications. Here, we aimed to analyse factors associated with HCQ retinopathy including HCQ blood levels. Methods This case...

Full description

Saved in:
Bibliographic Details
Published in:Rheumatology 2020-12, Vol.59 (12), p.3807-3816
Main Authors: Lenfant, Tiphaine, Salah, Sawsen, Leroux, Gaëlle, Bousquet, Elodie, Le Guern, Véronique, Chasset, François, Francès, Camille, Morel, Nathalie, Chezel, Julie, Papo, Thomas, Cacoub, Patrice, Mouthon, Luc, Guettrot-Imbert, Gaëlle, Cohen, Pascal, Régent, Alexis, Mauget-Faÿsse, Martine, Piette, Jean-Charles, Jallouli, Moez, Costedoat-Chalumeau, Nathalie
Format: Article
Language:English
Subjects:
Adult
Antirheumatic Agents - adverse effects
Case-Control Studies
Female
Humans
Hydroxychloroquine - adverse effects
Life Sciences
Lupus Erythematosus, Systemic - drug therapy
Male
Middle Aged
Original
Retinal Diseases - chemically induced
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Objective HCQ is an essential medication in SLE, proven to lengthen survival and reduce flares. Its use, however, is limited by its rare but severe ophthalmological complications. Here, we aimed to analyse factors associated with HCQ retinopathy including HCQ blood levels. Methods This case–control study compared SLE patients with and without HCQ retinopathy, defined by abnormal results for at least two of the following ophthalmological tests: automated visual fields, spectral-domain optical coherence tomography (SD-OCT), multifocal electroretinogram (mfERG) and fundus autofluorescence. We compared clinical and laboratory findings to assess risk factors for HCQ retinopathy. Results The study included 23 patients with confirmed retinopathy (cases) and 547 controls. In the univariate analysis, age (P 
ISSN:1462-0324
1462-0332
1460-2172
DOI:10.1093/rheumatology/keaa157