Mechanisms of action of ribosomally synthesized and posttranslationally modified peptides (RiPPs)

Natural products remain a critical source of medicines and drug leads. One of the most rapidly growing superclasses of natural products is RiPPs: ribosomally synthesized and posttranslationally modified peptides. RiPPs have rich and diverse bioactivities. This review highlights examples of the molec...

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Bibliographic Details
Published in:Journal of industrial microbiology & biotechnology 2021-04, Vol.48 (3-4), p.1
Main Authors: Cao, Li, Do, Truc, Link, A James
Format: Article
Language:English
Subjects:
Genomics
Natural Products
Peptides
Physiological aspects
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Summary:Natural products remain a critical source of medicines and drug leads. One of the most rapidly growing superclasses of natural products is RiPPs: ribosomally synthesized and posttranslationally modified peptides. RiPPs have rich and diverse bioactivities. This review highlights examples of the molecular mechanisms of action that underly those bioactivities. Particular emphasis is placed on RiPP/target interactions for which there is structural information. This detailed mechanism of action work is critical toward the development of RiPPs as therapeutics and can also be used to prioritize hits in RiPP genome mining studies.
ISSN:1367-5435
1476-5535
DOI:10.1093/jimb/kuab005