Efficient discrimination of transplutonium actinides by in vivo models

Transplutonium actinides are among the heaviest elements whose macroscale chemical properties can be experimentally tested. Being scarce and hazardous, their chemistry is rather unexplored, and they have traditionally been considered a rather homogeneous group, with most of their characteristics ext...

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Bibliographic Details
Published in:Chemical science (Cambridge) 2021-03, Vol.12 (14), p.5295-5301
Main Authors: Pallares, Roger M, An, Dahlia D, Deblonde, Gauthier J-P, Kullgren, Birgitta, Gauny, Stacey S, Jarvis, Erin E, Abergel, Rebecca J
Format: Article
Language:English
Subjects:
Actinides
Atomic properties
Biomimetics
Chelation
Chemical compounds
Chemical properties
Chemistry
Diethylenetriamine pentaacetic acid
Liver
Organs
Pharmacology
Radioactive wastes
Radioisotopes
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Summary:Transplutonium actinides are among the heaviest elements whose macroscale chemical properties can be experimentally tested. Being scarce and hazardous, their chemistry is rather unexplored, and they have traditionally been considered a rather homogeneous group, with most of their characteristics extrapolated from lanthanide surrogates. Newly emerged applications for these elements, combined with their persistent presence in nuclear waste, however, call for a better understanding of their behavior in complex living systems. In this work, we explored the biodistribution and excretion profiles of four transplutonium actinides ( Cm, Bk, Cf and Es) in a small animal model, and evaluated their sequestration and decorporation by two therapeutic chelators, diethylenetriamine pentaacetic acid and 3,4,3-LI(1,2-HOPO) Notably, the organ deposition patterns of those transplutonium actinides were element-dependent, particularly in the liver and skeleton, where lower atomic number radionuclides showed up to 7-fold larger liver/skeleton accumulation ratios. Nevertheless, the metal content in multiple organs was significantly decreased for all tested actinides, particularly in the liver, after administering the therapeutic agent 3,4,3-LI(1,2-HOPO) post-contamination. Lastly, the systematic comparison of the radionuclide biodistributions showed discernibly element-dependent organ depositions, which may provide insights into design rules for new bio-inspired chelating systems with high sequestration and separation performance.
ISSN:2041-6520
2041-6539
DOI:10.1039/d0sc06610a