Chia Seed Oil Ameliorates Doxorubicin-Induced Cardiotoxicity in Female Wistar Rats: An Electrocardiographic, Biochemical and Histopathological Approach

Doxorubicin (DOX) is a potent anti-cancer antibiotic that was widely used for treatment of various cancers. It produces free radicals which result in extreme dose-limiting cardiotoxicity. This study investigated the cardioprotective potential of chia seed oil, an active polyphenolic nutraceutical ag...

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Bibliographic Details
Published in:Cardiovascular toxicology 2021-07, Vol.21 (7), p.533-542
Main Authors: Ahmed, Akheruz Zaman, Mumbrekar, Kamalesh D., Satyam, Shakta Mani, Shetty, Prakashchandra, D’Souza, Melanie Rose, Singh, Varun Kumar
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Animals
Antibiotics
Antioxidants - pharmacology
Biomedical and Life Sciences
Biomedicine
Cancer
Cardiology
Cardiomyopathies - chemically induced
Cardiomyopathies - diagnosis
Cardiomyopathies - metabolism
Cardiomyopathies - prevention & control
Cardiotoxicity
Care and treatment
Chemotherapy
Creatine kinase
Depletion
Disease Models, Animal
Doxorubicin
Electrocardiogram
Electrocardiography
Extreme values
Female
Free radicals
Free radicals (Chemistry)
Functional foods & nutraceuticals
Myocytes, Cardiac - drug effects
Myocytes, Cardiac - metabolism
Myocytes, Cardiac - pathology
Oils & fats
Oilseeds
Oxidative Stress - drug effects
Pharmacology/Toxicology
Plant Extracts - pharmacology
Plant Oils - pharmacology
Rats
Rats, Wistar
Rodents
Salvia columbariae
Salvia hispanica
Seeds
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Summary:Doxorubicin (DOX) is a potent anti-cancer antibiotic that was widely used for treatment of various cancers. It produces free radicals which result in extreme dose-limiting cardiotoxicity. This study investigated the cardioprotective potential of chia seed oil, an active polyphenolic nutraceutical against doxorubicin-induced cardiotoxicity in Wistar rats. Twenty-four female Wistar rats were divided into four groups ( n  = 6) which consist of normal control, DOX control, test-A and test-B group. Animals were prophylactically treated with two different doses of test drug, i.e. chia seed oil 2.5 ml/kg/day and 5 ml/kg/day in test-A and test-B groups orally for 7 days. Doxorubicin (25 mg/kg; single dose) was administered intraperitoneally to DOX control, Test-A and Test-B animals on the seventh day to induce cardiotoxicity. ECG analysis was done before and after treatment. Besides ECG, CK, CK-MB, LDH, AST, MDA and GSH were analyzed. DOX had significantly altered ECG, CK, CK-MB, LDH, AST, MDA and GSH. Pre-treatment with chia seed oil significantly alleviated DOX-induced ECG changes and also guarded against DOX-induced rise of serum CK, CK-MB and AST levels. Chia seed oil alleviated histopathological alteration in DOX-treated rats. It also significantly inhibited DOX-induced GSH depletion and elevation of MDA. The present study revealed that chia seed oil exerts cardioprotection against doxorubicin-induced cardiotoxicity in female Wistar rats. Our study opens the perspective to clinical studies to precisely consider chia seed oil as a potential chemoprotectant nutraceutical in the combination chemotherapy with doxorubicin to limit its cardiotoxicity.
ISSN:1530-7905
1559-0259
DOI:10.1007/s12012-021-09644-3