Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors

Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of chronic liver disease in the Western world, probably due to the growing prevalence of obesity, metabolic diseases, and exposure to some environmental agents. In certain patients, simple hepatic steatosis can progress to...

Full description

Saved in:
Bibliographic Details
Published in:International journal of environmental research and public health 2021-05, Vol.18 (10), p.5227
Main Authors: Juanola, Oriol, Martínez-López, Sebastián, Francés, Rubén, Gómez-Hurtado, Isabel
Format: Article
Language:English
Subjects:
Biopsy
Body mass index
Cirrhosis
Complications
Diabetes
Endoplasmic reticulum
Environmental risk
Epidemiology
Epigenetics
Fatty acids
Fatty liver
Gastrointestinal surgery
Hepatocellular carcinoma
Hypertension
Inflammation
Insulin
Insulin resistance
Intestinal microflora
Liver
Liver cirrhosis
Liver diseases
Metabolic disorders
Metabolic syndrome
Microbiota
Obesity
Oxidative stress
Population
Resistance factors
Review
Risk analysis
Risk factors
Stability
Steatosis
Triglycerides
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of chronic liver disease in the Western world, probably due to the growing prevalence of obesity, metabolic diseases, and exposure to some environmental agents. In certain patients, simple hepatic steatosis can progress to non-alcoholic steatohepatitis (NASH), which can sometimes lead to liver cirrhosis and its complications including hepatocellular carcinoma. Understanding the mechanisms that cause the progression of NAFLD to NASH is crucial to be able to control the advancement of the disease. The main hypothesis considers that it is due to multiple factors that act together on genetically predisposed subjects to suffer from NAFLD including insulin resistance, nutritional factors, gut microbiota, and genetic and epigenetic factors. In this article, we will discuss the epidemiology of NAFLD, and we overview several topics that influence the development of the disease from simple steatosis to liver cirrhosis and its possible complications.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph18105227