Survival and prognostic factors in patients with oral squamous cell carcinoma

This study aimed to evaluate sociodemographic and clinical factors influencing overall survival (OS) in patients with oral squamous cell carcinoma (OSCC). Medical charts of 547 patients with OSCC from a public hospital in northeastern Brazil seen between 1999 and 2013 were evaluated. Survival analys...

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Bibliographic Details
Published in:Medicina oral, patología oral y cirugía bucal patología oral y cirugía bucal, 2021-05, Vol.26 (3), p.e387-e392
Main Authors: Ferreira, A-K, Carvalho, S-H, Granville-Garcia, A-F, Sarmento, D-J, Agripino, G-G, Abreu, M-H, Melo, M-C, Caldas, Jr, A-D, Godoy, G-P
Format: Article
Language:English
Subjects:
Adult
Brazil
Carcinoma, Squamous Cell - therapy
Dentistry
Head and Neck Neoplasms
Humans
Mouth Neoplasms - therapy
Prognosis
Retrospective Studies
Squamous Cell Carcinoma of Head and Neck
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Summary:This study aimed to evaluate sociodemographic and clinical factors influencing overall survival (OS) in patients with oral squamous cell carcinoma (OSCC). Medical charts of 547 patients with OSCC from a public hospital in northeastern Brazil seen between 1999 and 2013 were evaluated. Survival analysis was performed using the Kaplan-Meier method. The influence of age, sex, ethnicity, clinical stage, anatomical location, type of treatment, and comorbidities on the patients' prognosis was evaluated. Cox proportional hazards regression model was used to identify independent prognostic factors. The 5-year OS was 39%. Multivariate analysis showed that age < 40 years (HR = 2.20; 95%CI: 1.02-4.72) and a single treatment modality (HR = 1.91; 95%CI: 1.37-2.67) were associated with a poor prognosis, while early clinical stage resulted in better outcomes (HR = 0.38; 95%CI: 0.25-0.58). OSCC patients in advanced clinical stages, diagnosed at a younger age, and submitted to a single therapeutic modality have a poorer prognosis.
ISSN:1698-6946
1698-4447
1698-6946
DOI:10.4317/medoral.24242