Elevated MUC5AC expression is associated with mismatch repair deficiency and proximal tumor location but not with cancer progression in colon cancer

Mucin 5AC (MUC5AC) is a secreted gel-forming mucin expressed by several epithelia. In the colon, MUC5AC is expressed in scattered normal epithelial cells but can be abundant in colorectal cancers. To clarify the relationship of MUC5AC expression with parameters of tumor aggressiveness and mismatch r...

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Bibliographic Details
Published in:Medical molecular morphology 2021-06, Vol.54 (2), p.156-165
Main Authors: Rico, Sebastian Dwertmann, Höflmayer, Doris, Büscheck, Franziska, Dum, David, Luebke, Andreas M., Kluth, Martina, Hube-Magg, Claudia, Hinsch, Andrea, Möller-Koop, Christina, Perez, Daniel, Izbicki, Jakob R., Neipp, Michael, Mofid, Hamid, Lárusson, Hannes, Daniels, Thies, Isbert, Christoph, Coerper, Stephan, Ditterich, Daniel, Rupprecht, Holger, Goetz, Albert, Fraune, Christoph, Möller, Katharina, Menz, Anne, Bernreuther, Christian, Clauditz, Till S., Sauter, Guido, Uhlig, Ria, Wilczak, Waldemar, Simon, Ronald, Steurer, Stefan, Lebok, Patrick, Burandt, Eike, Krech, Till, Marx, Andreas H.
Format: Article
Language:English
Subjects:
Aged
Anatomy
Cecum
Colon cancer
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Disease Progression
DNA Mismatch Repair
Epithelial cells
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Localization
Medicine
Medicine & Public Health
Mismatch repair
Molecular Medicine
Mucin
Mucin 5AC - genetics
Multivariate analysis
Original Paper
Pathology
Rectum
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Summary:Mucin 5AC (MUC5AC) is a secreted gel-forming mucin expressed by several epithelia. In the colon, MUC5AC is expressed in scattered normal epithelial cells but can be abundant in colorectal cancers. To clarify the relationship of MUC5AC expression with parameters of tumor aggressiveness and mismatch repair deficiency (dMMR) in colorectal cancer, a tissue microarray containing 1812 colorectal cancers was analyzed by immunohistochemistry. MUC5AC expression was found in 261 (15.7%) of 1,667 analyzable colorectal cancers. MUC5AC expression strongly depended on the tumor location and gradually decreased from proximal (27.4% of cecum cancers) to distal (10.6% of rectal cancers; p  
ISSN:1860-1480
1860-1499
DOI:10.1007/s00795-020-00274-2