Regional Cerebral Blood Flow Using Quantitative MR Angiography

We sought to derive regional cerebral blood flow using vessel flows from quantitative MR angiography (qMRA). Flow rates in the 15 major cerebral arteries were measured on retrospectively gated fast 2D phase-contrast MR angiography obtained in 83 healthy adult volunteers (age range, 24-74 years; mean...

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Bibliographic Details
Published in:American Journal of Neuroradiology 2007-09, Vol.28 (8), p.1470-1473
Main Authors: Zhao, M, Amin-Hanjani, S, Ruland, S, Curcio, A.P, Ostergren, L, Charbel, F.T
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Aged
Aging - physiology
Algorithms
Biological and medical sciences
Brain
Cardiovascular system
Carotid Artery, Common - physiology
Cerebrovascular Circulation
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Angiography
Male
Medical sciences
Middle Aged
Miscellaneous
Mood disorders
Nervous system
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Reference Values
Regional Blood Flow
Retrospective Studies
Sex Factors
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Summary:We sought to derive regional cerebral blood flow using vessel flows from quantitative MR angiography (qMRA). Flow rates in the 15 major cerebral arteries were measured on retrospectively gated fast 2D phase-contrast MR angiography obtained in 83 healthy adult volunteers (age range, 24-74 years; mean, 42 years). The arterial network of the brain was partitioned into 12 different regions, in which flows were calculated from the measured flows of the 15 cerebral arteries. The mean flows of the 15 arteries and the 12 regions were calculated. The mean total cranial flow and the mean total cerebral blood flow were 949 +/- 158 mL/min and 695 +/- 113 mL/min, respectively. The mean regional flows for the anterior and posterior circulation were 483 +/- 87 mL/min and 212 +/- 34 mL/min, respectively. The relative contributions of the flows in the 11 regions to their parent regions were obtained. The mean flows in the individual arteries and the regions with age were also calculated. The mean flows for the female group were significantly lower than those for the male group (P < .001) for the 2 common carotids and the cranial circulation and left/right extracranial circulation. However, the intracranial circulation was not different between sexes. The 12 regions in the cerebral circulation were identified and formed into a partition tree, and the mean regional flow for each region was determined using vessel flows from qMRA.
ISSN:0195-6108
1936-959X
1432-1920
DOI:10.3174/ajnr.A0582