Effects of Cannabinoids on Sleep and their Therapeutic Potential for Sleep Disorders

The recent trend for legalization of medicinal cannabis and cannabinoid-containing products, together with their soporific effects, has led to a surge of interest of their potential therapeutic role in the management of some common sleep disorders, such as insomnia, sleep disordered breathing, and r...

Full description

Saved in:
Bibliographic Details
Published in:Neurotherapeutics 2021, Vol.18 (1), p.217-227
Main Authors: Kaul, Malvika, Zee, Phyllis C., Sahni, Ashima S.
Format: Article
Language:English
Subjects:
Apnea
Biomedical and Life Sciences
Biomedicine
Cannabinoids
Cannabinoids - pharmacology
Cannabinoids - therapeutic use
Cannabis
Clinical trials
Humans
Insomnia
Narcolepsy
Neurobiology
Neurology
Neurosciences
Neurosurgery
Restless legs syndrome
Review
Sleep - drug effects
Sleep apnea
Sleep disorders
Sleep Wake Disorders - drug therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The recent trend for legalization of medicinal cannabis and cannabinoid-containing products, together with their soporific effects, has led to a surge of interest of their potential therapeutic role in the management of some common sleep disorders, such as insomnia, sleep disordered breathing, and restless legs syndrome, and less common disorders such as narcolepsy and parasomnias. Although much of the pre-clinical and clinical data were derived from studies with relatively small sample sizes and limited by biases in assessment, and in clinical trials lack of allocation concealment, as a whole, the results indicate a potential therapeutic role for cannabinoids in the management of some sleep disorders. Clinical trials are underway for insomnia and obstructive sleep apnea management, but there remains a substantial need for rigorous large multi-center studies to assess the dose, efficacy, and safety of the various types of cannabinoids on sleep disorders. This review aims to summarize the modulatory effects of cannabinoids on sleep physiology and provide a critical evaluation of the research on their potential therapeutic benefit in various sleep disorders.
ISSN:1933-7213
1878-7479
1878-7479
DOI:10.1007/s13311-021-01013-w