Antiproliferative and antibacterial potential of tetrahexylammonium bromide-based ionic liquids

Ionic liquids (ILs) exhibit cytotoxic effects on prokaryotic and eukaryotic cells. In this study, the antibacterial and antiproliferative activities of tetrahexylammonium bromide-based ILs were investigated. In order to evaluate the therapeutic potential of these ionic liquids, firstly microbiologic...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2021-07, Vol.22 (1), p.672-672, Article 672
Main Authors: Popescu, Roxana, Filimon, Marioara Nicoleta, Vlad, Daliborca Cristina, Verdes, Doina, Moatar, Aurica, Moise, Georgiana, Guran, Kristine, Caraba, Ion Valeriu, Ciochina, Liliana Petculescu, Pinzaru, Iulia, Dehelean, Cristina Adriana, Dumitrescu, Gabi
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
Bacteria
Bacterial infections
Cancer
Care and treatment
Cell culture
Cytotoxicity
E coli
Gram-positive bacteria
Health aspects
Investigations
Ionic liquids
Microorganisms
Pharmacology, Experimental
Salmonella
Streptococcus infections
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Summary:Ionic liquids (ILs) exhibit cytotoxic effects on prokaryotic and eukaryotic cells. In this study, the antibacterial and antiproliferative activities of tetrahexylammonium bromide-based ILs were investigated. In order to evaluate the therapeutic potential of these ionic liquids, firstly microbiological assay using both Gram-positive and Gram-negative bacteria were conducted by employing Disk-Diffusion and 2,3,5-triphenyltetrazolium chlorine (TTC) methods to assess the antimicrobial effects. Likewise, the antitumor effects on 2D and 3D cell culture systems were assessed using the human colon cancer Caco-2 cell line and cytotoxic activity was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and Alamar blue assays. Results obtained showed that [CH (CH ) ] N(Br) possesses an antibacterial potential, particularly in the case of two bacteria, (Gram ) and (Gram ) Preliminary screening of antiproliferative activity showed moderate activity, except for the concentration of 10 mM. Furthermore, regarding the effect of [CH (CH ) ] N(Br) on tumor cell aggregation, positive outcomes were noted. [CH (CH ) ] N(Br) presents promising and under-explored potential to improve antibacterial or anticancer therapies.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2021.10104