The effect of acute rises in intraocular pressure after intravitreal bevacizumab injection on the peripapillary retinal nerve fiber layer thickness and the role of anterior chamber paracentesis

Purpose: To evaluate acute changes in intraocular pressure (IOP) and their short-term effects on the peripapillary retinal nerve fiber layer (RNFL) thickness after intravitreal bevacizumab (IVB) injection. Methods: Fifty-eight eyes of 37 patients with treatment-naïve diabetic macular edema or exudat...

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Bibliographic Details
Published in:Iranian journal of ophthalmology 2021-01, Vol.33 (1), p.12-16
Main Authors: Khodabande, Alireza, Zarei, Mohammad, Khojasteh, Hasan, Mohammadi, Massood, Asadi Khameneh, Esmaeil, Torkashvand, Ali, Davoodabadi, Mahmood
Format: Article
Language:English
Subjects:
Care and treatment
Macular degeneration
Medical research
Medicine, Experimental
Monoclonal antibodies
Ophthalmology
Original
Retina
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Summary:Purpose: To evaluate acute changes in intraocular pressure (IOP) and their short-term effects on the peripapillary retinal nerve fiber layer (RNFL) thickness after intravitreal bevacizumab (IVB) injection. Methods: Fifty-eight eyes of 37 patients with treatment-naïve diabetic macular edema or exudative age-related macular degeneration were included in the study. Patients were divided into two groups, and the participants of each group received 3 monthly injections of IVB. IOP was measured right before the injection, immediately after the injection, and 5 min and 20 min after each injection. Peripapillary, RNFL thickness was measured before the injection and 1 month after the third injection. In the second group, anterior chamber (AC) paracentesis was performed before IVB injection. Results: IOP values after injection in all sessions were significantly higher in the first group (P < 0.001). The peripapillary RNFL thickness changes 1 month after the third injection was not statistically significantly different in each group (P = 0.816 and 0.773 for the first and second groups, respectively). Conclusion: AC paracentesis is an effective modality to reduce the acute rise in IOP. The effect of acute IOP elevation on the peripapillary RNFL thickness was not statistically significant.
ISSN:2452-2325
2452-2325
DOI:10.4103/JOCO.JOCO_214_20