Sex-based disparity in paraoxonase-2 expression in the brains of African green monkeys

The development of several neurodegenerative disorders, such as Parkinson's disease, has been linked with decreased mitochondrial performance, leading to oxidative stress as a result of increased production of reactive oxygen species (ROS). Previous studies have established that the mitochondri...

Full description

Saved in:
Bibliographic Details
Published in:Free radical biology & medicine 2021-05, Vol.167, p.201-204
Main Authors: Jamwal, Sumit, Blackburn, Jennifer K., Elsworth, John D.
Format: Article
Language:English
Subjects:
Animals
Aryldialkylphosphatase - genetics
Aryldialkylphosphatase - metabolism
Brain - metabolism
Chlorocebus aethiops
Female
Male
Mitochondria - metabolism
Neuroprotection
Oxidative Stress
Paraoxonase-2
Parkinson's disease
Reactive Oxygen Species - metabolism
Sex
Striatum
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The development of several neurodegenerative disorders, such as Parkinson's disease, has been linked with decreased mitochondrial performance, leading to oxidative stress as a result of increased production of reactive oxygen species (ROS). Previous studies have established that the mitochondrial enzyme, paraoxonase-2 (PON2), possesses potent antioxidant and anti-inflammatory properties, with its expression linked with lower ROS levels. The aim of this study was to explore the sex-based variations in the protein level of PON2 in different brain regions (striatum, hippocampus, occipital cortex, and dorsolateral prefrontal cortex) of African green monkeys. Our results revealed that the PON2 expression in females was significantly higher than in males, in each of the examined brain regions. As Parkinson's disease is more prevalent in males compared with females and is characterized by oxidative stress in the nigrostriatal system, these findings add to the growing evidence for PON2 as a target for development of therapeutics to combat this disorder. [Display omitted] •Paraoxonase-2 possesses potent antioxidant and anti-inflammatory properties and its expression decreases with age.•Paraoxonase-2 protein expression in female monkeys was significantly higher than in male monkeys in multiple brain regions.•Reduced Paraoxonase-2 expression may contribute to the higher incidence of some disorders in males.•Paraoxonase-2 is a therapeutic target for oxidative stress-associated neurodegenerative disorders like Parkinson's disease.
ISSN:0891-5849
1873-4596
DOI:10.1016/j.freeradbiomed.2021.03.003