Predicting lung fibrosis in post-COVID-19 patients after discharge with follow-up chest CT findings

Background Coronavirus disease has spread widely all over the world since the beginning of 2020, and this required rapid adequate management. High-resolution computed tomography (HRCT) has become an initial valuable tool for screening, diagnosis, and assessment of disease severity. This study aimed...

Full description

Saved in:
Bibliographic Details
Published in:Egyptian journal of radiology and nuclear medicine 2021-05, Vol.52 (1), p.118-13
Main Authors: Yasin, Rabab, Gomaa, Ahmed Abdelhakim Kamel, Ghazy, Tamer, Hassanein, Shaimaa Abdelhamid, Ibrahem, Reda Abdel latif, Khalifa, Mohamed Hossameldin
Format: Article
Language:English
Subjects:
Age
C-reactive protein
Consolidation
Coronavirus infections
Coronaviruses
COVID-19
CT imaging
Diagnostic imaging
Disease transmission
Females
Ferritin
Fibrosis
Follow-up CT, Lung fibrosis
Health aspects
Hospital patients
Hospitalization
Infection
Infections
Laboratories
Length of stay
Males
Medical imaging
Medical research
Medicine, Experimental
Pandemics
Patients
Pulmonary fibrosis
Respiratory diseases
Risk factors
Severe acute respiratory syndrome coronavirus 2
Steroids
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Coronavirus disease has spread widely all over the world since the beginning of 2020, and this required rapid adequate management. High-resolution computed tomography (HRCT) has become an initial valuable tool for screening, diagnosis, and assessment of disease severity. This study aimed to assess the clinical, radiographic, and laboratory findings of COVID-19 with HRCT follow-up in discharged patients to predict lung fibrosis after COVID-19 infection in survived patients. Results This study included two-hundred and ten patients who were tested positive for the novel coronavirus by nasopharyngeal swap, admitted to the hospital, and discharged after recovery. Patients with at least a one-time chest CT scan after discharge were enrolled. According to the presence of fibrosis on follow-up CT after discharge, patients were classified into two groups and assigned as the "non-fibrotic group" (without evident fibrosis) and "fibrotic group" (with evident fibrosis). We compared between these two groups based on the recorded clinical data, patient demographic information (i.e., sex and age), length of stay (LOS) in the hospital, admission to the ICU, laboratory results (peak C-reactive protein [CRP] level, lowest lymphocyte level, serum ferritin, high-sensitivity troponin, d-dimer, administration of steroid), and CT features (CT severity score and CT consolidation/crazy-paving score). CT score includes the CT during the hospital stay with peak opacification and follow-up CT after discharge. The average CT follow-up time after discharge is 41.5 days (range, 20 to 65 days). There was a statistically significant difference between both groups (p Ë0.001). Further, a multivariate analysis was performed and found that the age of the patients, initial CT severity score, consolidation/crazy-paving score, and ICU admission were independent risk factors associated with the presence of post-COVID-19 fibrosis (p
ISSN:0378-603X
2090-4762
DOI:10.1186/s43055-021-00495-0