Burden of high blood pressure as a contributing factor to stroke in the Japanese community-based diabetic population

Diabetes mellitus is characterized by alterations in blood glucose (BG) metabolism, and glycated hemoglobin (HbA c) has been widely used as a marker of the BG concentration. Diabetes often coexists with high blood pressure (BP). High BP and hyperglycemia are well-known risk factors of stroke. We exa...

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Bibliographic Details
Published in:Hypertension research 2018-07, Vol.41 (7), p.531-538
Main Authors: Komi, Ryosuke, Tanaka, Fumitaka, Omama, Shinichi, Ishibashi, Yasuhiro, Tanno, Kozo, Onoda, Toshiyuki, Ohsawa, Masaki, Tanaka, Kentaro, Okayama, Akira, Nakamura, Motoyuki
Format: Article
Language:English
Subjects:
Aged
Blood Glucose
Blood Pressure - physiology
Blood Pressure Determination
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - physiopathology
Female
Humans
Hypertension
Hypertension - complications
Hypertension - physiopathology
Incidence
Japan - epidemiology
Male
Middle Aged
Population
Risk Factors
Stroke
Stroke - epidemiology
Stroke - etiology
Stroke - physiopathology
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Summary:Diabetes mellitus is characterized by alterations in blood glucose (BG) metabolism, and glycated hemoglobin (HbA c) has been widely used as a marker of the BG concentration. Diabetes often coexists with high blood pressure (BP). High BP and hyperglycemia are well-known risk factors of stroke. We examined the extent to which the increased risk of stroke in diabetic individuals is attributable to BP and BG using prospectively collected data from the Japanese general population. During an average 8.3 ± 2.2 years of follow-up, out 1606 diabetic individuals aged ≥40 years who were free of cardiovascular disease, 119 participants (7.4%) developed stroke. In multivariable analysis, a significant difference in the risk of incident stroke was noted among the BP categories, including normotension (BP1), prehypertension (BP2), and hypertension (BP3; P for trend = 0.001). By contrast, no difference was noted among the BG categories, including HbA c levels
ISSN:0916-9636
1348-4214
DOI:10.1038/s41440-018-0042-4