Serum Krebs von den Lungen-6 levels are associated with mortality and severity in patients with coronavirus disease 2019

The serum Krebs von den Lungen-6 (KL-6) level is a predictive factor for acute respiratory distress syndrome (ARDS). The development of ARDS has been reported in patients with coronavirus disease 2019 (COVID-19). This study aimed to determine whether serum KL-6 levels are associated with mortality a...

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Published in:Respiratory investigation 2021-09, Vol.59 (5), p.596-601
Main Authors: Yamaya, Takafumi, Hagiwara, Eri, Baba, Tomohisa, Kitayama, Takaaki, Murohashi, Kota, Higa, Katsuyuki, Sato, Yozo, Otoshi, Ryota, Tabata, Erina, Shintani, Ryota, Okabayashi, Hiroko, Ikeda, Satoshi, Niwa, Takashi, Nakazawa, Atsuhito, Oda, Tsuneyuki, Okuda, Ryo, Sekine, Akimasa, Kitamura, Hideya, Komatsu, Shigeru, Ogura, Takashi
Format: Article
Language:English
Subjects:
Coronavirus disease 2019
Krebs von den Lungen-6
Original
Prognosis
Severity
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Summary:The serum Krebs von den Lungen-6 (KL-6) level is a predictive factor for acute respiratory distress syndrome (ARDS). The development of ARDS has been reported in patients with coronavirus disease 2019 (COVID-19). This study aimed to determine whether serum KL-6 levels are associated with mortality and severity in patients with COVID-19. Among 361 Japanese patients with COVID-19 who were hospitalized at Kanagawa Cardiovascular and Respiratory Center between February 2020 and December 2020, 356 patients with data on serum KL-6 levels were enrolled and their medical records were retrospectively analyzed. A negative correlation was observed between KL-6 levels and the ratio of the arterial partial pressure of oxygen to the fraction of inspired oxygen on admission. The KL-6 levels on admission and the maximal KL-6 levels were higher in patients with severe disease (n = 60) than in those with nonsevere disease (n = 296). Furthermore, the maximal KL-6 levels were higher in nonsurvivors (n = 6) than in survivors (n = 350). In nonsurvivors, the KL-6 levels increased as the disease progressed. The optimal cutoff value of the maximal KL-6 level for discriminating between survivors and nonsurvivors was 684 U/mL, with a sensitivity of 83.3%, a specificity of 90.5%, and an area under the curve of 0.89. The serum KL-6 level was associated with disease severity. Patients with KL-6 levels ≥684 U/mL had a significantly poorer outcome than those with KL-6 levels
ISSN:2212-5345
2212-5353
DOI:10.1016/j.resinv.2021.04.002