Lithium enhances exercise-induced glycogen breakdown and insulin-induced AKT activation to facilitate glucose uptake in rodent skeletal muscle

The purpose of this study was to investigate the effect of lithium on glucose disposal in a high-fat diet-induced type 2 diabetes mellitus (T2DM) and streptozotocin-induced type 1 diabetes mellitus (T1DM) animal model along with low-volume exercise and low-dose insulin. Lithium decreased body weight...

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Bibliographic Details
Published in:Pflügers Archiv 2021-04, Vol.473 (4), p.673-682
Main Authors: Jung, Su-Ryun, Park, Sol-Yi, Koh, Jin-Ho, Kim, Jong-Yeon
Format: Article
Language:English
Subjects:
AKT protein
Animal models
Animals
Biomedical and Life Sciences
Biomedicine
Body weight
Cell Biology
Dephosphorylation
Diabetes
Diabetes mellitus (insulin dependent)
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - metabolism
Dosage
Glucose
Glucose - metabolism
Glycogen
Glycogen - metabolism
High fat diet
Human Physiology
Insulin
Insulin - pharmacology
Lithium
Lithium - pharmacology
Male
Mice
Mice, Inbred C57BL
Molecular Medicine
Muscle Physiology
Muscle, Skeletal - drug effects
Muscle, Skeletal - metabolism
Muscle, Skeletal - physiopathology
Neurosciences
Physical Conditioning, Animal - methods
Physical training
Proto-Oncogene Proteins c-akt - metabolism
Rats
Rats, Sprague-Dawley
Rats, Wistar
Receptors
Serine
Skeletal muscle
Streptozocin
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Summary:The purpose of this study was to investigate the effect of lithium on glucose disposal in a high-fat diet-induced type 2 diabetes mellitus (T2DM) and streptozotocin-induced type 1 diabetes mellitus (T1DM) animal model along with low-volume exercise and low-dose insulin. Lithium decreased body weight, fasting plasma glucose, and insulin levels when to treat with low-volume exercise training; however, there were no adaptive responses like an increase in GLUT4 content and translocation factor levels. We discovered that lithium enhanced glucose uptake by acute low-volume exercise-induced glycogen breakdown, which was facilitated by the dephosphorylation of serine 473-AKT (Ser473-AKT) and serine 9-GSK3β. In streptozotocin-induced T1DM mice, Li/low-dose insulin facilitates glucose uptake through increase the level of exocyst complex component 7 (Exoc7) and Ser473-AKT. Thus, lithium enhances acute exercise-induced glycogen breakdown and insulin-induced AKT activation and could serve as a candidate therapeutic target to regulate glucose level of DM patients.
ISSN:0031-6768
1432-2013
DOI:10.1007/s00424-021-02543-0