Perinatal outcomes of pregnancies resulting from assisted reproduction technology in SARS-CoV-2-infected women: a prospective observational study

To evaluate the perinatal and maternal outcomes of pregnancies in women infected with SARS-CoV-2, comparing spontaneous and in vitro fertilization (IVF) pregnancies (with either own or donor oocytes). Multicenter, prospective, observational study. 78 centers participating in the Spanish COVID19 Regi...

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Published in:Fertility and sterility 2021-09, Vol.116 (3), p.731-740
Main Authors: Engels Calvo, Virginia, Cruz Melguizo, Sara, Abascal-Saiz, Alejandra, Forcén Acebal, Laura, Sánchez-Migallón, Amalia, Pintado Recarte, Pilar, Cuenca Marín, Celia, Marcos Puig, Beatriz, Del Barrio Fernández, Pablo G., Nieto Velasco, Olga, de la Cruz Conty, María Luisa, Martínez-Perez, Oscar, Garrido Luque, María Belén, Fernández, Camino Fernández, Yarza, Ana Villalba, Canedo Carballeira, Esther María, Dueñas Carazo, María Begoña, Aguilar, Rosario Redondo, Sánchez-Vegazo García, Ángeles, Silvares, Esther Álvarez, Pardo Pumar, María Isabel, Álvarez-Mallo, Macarena Alférez, Carmona, Víctor Muñoz, Pérez, Noelia Pérez, Colomo, Cristina Álvarez, Mateu, Onofre Alomar, Di Leo, Claudio Marañon, Millán, María del Carmen Parada, García, Adrián Martín, Martínez, José Navarrina, Fornell, Anna Mundó, Salvador, Elena Pascual, Gómez, Tania Manrique, Meca Casbas, Marta Ruth, Grimalt, Noemí Freixas, Aquise, Adriana, Gil, María del Mar, Amorós, Eduardo Cazorla, Sánchez, Alberto Armijo, Conca Rodero, María Isabel, Oreja Cuesta, Ana Belén, Aguilar, Cristina Ruiz, García, Susana Fernández, Gómez, Mercedes Ramírez, Aguilar Galán, Esther Vanessa, Pérez, Rocío López, Luque, Carmen Baena, Jiménez Losa, Luz María, Pérez, Susana Soldevilla, Granell Escobar, María Reyes, González, Manuel Domínguez, Blaya, Flora Navarro, Wizner de Alva, Juan Carlos, Carulla, Rosa Pedró, Sánchez, Encarnación Carmona, Rodríguez, Judit Canet, Antolín, Eva Morán, Macià, Montse, Pratcorona, Laia, Abásolo, Irene Gastaca, Borde, Begoña Martínez, Ruiz, Óscar Vaquerizo, Aragón, José Ruiz, Seoane, Raquel González, González, María Teulón, González, Lourdes Martín, Heredia, Cristina Lesmes, Broullón Molanes, J. Román, Gimeno Gimeno, María Joaquina, Posadas San Juan, Alma María, Vanegas, Otilia González, Fernández Alonso, Ana María, Meca, Lucía Díaz, Prieto, Alberto Puerta, Martín, María del Pilar Guadix, Orizales Lago, Carmen María, Sainz Bueno, José Antonio, Coello, Mónica Catalina, José Núñez Valera, María, González, Lucas Cerrillos, García, José Adanez, Ferriols-Pérez, Elena, Roqueta, Marta, Encinas Pardilla, María Begoña, Sánchez, Marta García, Rodríguez, Laura González, Recarte, Pilar Pintado, Paredes, Elena Pintado, Payán, Paola Carmona, Iriarte, Yosu Franco, San Frutos Llorente, Luis
Format: Article
Language:English
Subjects:
assisted reproduction
cohort study
COVID-19
intensive care unit
Original
pregnancy
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Summary:To evaluate the perinatal and maternal outcomes of pregnancies in women infected with SARS-CoV-2, comparing spontaneous and in vitro fertilization (IVF) pregnancies (with either own or donor oocytes). Multicenter, prospective, observational study. 78 centers participating in the Spanish COVID19 Registry. 1,347 pregnant women with SARS-CoV-2 positive results registered consecutively between February 26 and November 5, 2020. The patients’ information was collected from their medical records, and multivariable regression analyses were performed, controlling for maternal age and the clinical presentation of the infection. Obstetrics and neonatal outcomes, pregnancy comorbidities, intensive care unit admission, mechanical ventilation need, and medical conditions. The IVF group included 74 (5.5%) women whereas the spontaneous pregnancy group included 1,275 (94.5%) women. The operative delivery rate was high in all patients, especially in the IVF group, where cesarean section became the most frequent method of delivery (55.4%, compared with 26.1% of the spontaneous pregnancy group). The reason for cesarean section was induction failure in 56.1% of the IVF patients. IVF women had more gestational hypertensive disorders (16.2% vs. 4.5% among spontaneous pregnancy women, adjusted odds ratio [aOR] 5.31, 95% confidence interval [CI] 2.45–10.93) irrespective of oocyte origin. The higher rate of intensive care unit admittance observed in the IVF group (8.1% vs. 2.4% in the spontaneous pregnancy group) was attributed to preeclampsia (aOR 11.82, 95% CI 5.25–25.87), not to the type of conception. A high rate of operative delivery was observed in pregnant women infected with SARS-CoV-2, especially in those with IVF pregnancies; method of conception did not affect fetal or maternal outcomes, except for preeclampsia. NCT04558996. Resultados perinatales en embarazos resultante de técnicas de reproducción asistida en mujeres infectadas con SARS-CoV-2: un estudio observacional prospectivo. Evaluar los resultados perinatales y maternos de los embarazos en mujeres infectadas con SARS-CoV-2, comparando embarazos espontáneos con los de fecundación in vitro (FIV) (con ovocitos propios o de donantes). Estudio observacional, prospectivo, multicéntrico. 78 centros participantes en el Registro Español COVID19 1347 mujeres embarazadas con resultados positivos de SARS-CoV-2 registrados consecutivamente entre el 26 de febrero y el 5 de noviembre de 2020. ): La información de las pacientes s
ISSN:0015-0282
1556-5653
1556-5653
DOI:10.1016/j.fertnstert.2021.04.005