Low‐Dose Aspirin for Preventing Preeclampsia and Its Complications: A Meta‐Analysis

Low‐dose aspirin (LDA) is thought to prevent preeclampsia in high‐risk pregnancy, but it is not universally used out of concern for its efficacy and safety. The authors meta‐analyzed 29 randomized controlled trials (RCTs) to evaluate LDA for preventing preeclampsia and its complications. LDA can red...

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Bibliographic Details
Published in:The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2015-07, Vol.17 (7), p.567-573
Main Authors: Xu, Ting‐ting, Zhou, Fan, Deng, Chun‐yan, Huang, Gui‐qiong, Li, Jin‐ke, Wang, Xiao‐dong
Format: Article
Language:English
Subjects:
Aspirin - administration & dosage
Female
Fetal Growth Retardation - prevention & control
Humans
Infant, Newborn
Platelet Aggregation Inhibitors - administration & dosage
Pre-Eclampsia - diagnosis
Pre-Eclampsia - prevention & control
Pregnancy
Randomized Controlled Trials as Topic - methods
Review Paper
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Summary:Low‐dose aspirin (LDA) is thought to prevent preeclampsia in high‐risk pregnancy, but it is not universally used out of concern for its efficacy and safety. The authors meta‐analyzed 29 randomized controlled trials (RCTs) to evaluate LDA for preventing preeclampsia and its complications. LDA can reduce the incidence of preeclampsia (odds ratio [OR], 0.71; 95% confidence interval [CI], 0.57–0.87), severe preeclampsia (OR, 0.37; 95% CI, 0.23–0.61), preterm birth (OR, 0.81; 95% CI, 0.75–0.88), and intrauterine growth restriction (IUGR) (OR, 0.80; 95% CI, 0.71–0.90). LDA is more effective in reducing incidence of preeclampsia or IUGR if used before 16 gestational weeks than if used later. LDA increases the incidence of placental abruption (OR, 1.35; 95% CI, 1.05–1.73) but not other major complications. The available evidence suggests that LDA is effective in preventing preeclampsia, preterm birth, and IUGR in high‐risk pregnancies without posing a major safety risk to mothers or fetuses.
ISSN:1524-6175
1751-7176
DOI:10.1111/jch.12541