Modulating autophagy as a therapeutic strategy for the treatment of paediatric high‐grade glioma

Paediatric high‐grade gliomas (pHGG) represent a therapeutically challenging group of tumors. Despite decades of research, there has been minimal improvement in treatment and the clinical prognosis remains poor. Autophagy, a highly conserved process for recycling metabolic substrates is upregulated...

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Bibliographic Details
Published in:Brain pathology (Zurich, Switzerland) Switzerland), 2019-11, Vol.29 (6), p.707-725
Main Authors: Howarth, Alison, Madureira, Patricia A., Lockwood, George, Storer, Lisa C. D., Grundy, Richard, Rahman, Ruman, Pilkington, Geoffrey J., Hill, Richard
Format: Article
Language:English
Subjects:
Autophagy
Autophagy - physiology
Brain Neoplasms - pathology
Brain tumors
Cell death
Child
Child, Preschool
Crosstalk
Female
Glioma
Glioma - pathology
Glioma - therapy
Humans
Male
paediatric high grade glioma
Phagocytosis
Prognosis
Review
Substrates
Therapeutic applications
Tumors
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Summary:Paediatric high‐grade gliomas (pHGG) represent a therapeutically challenging group of tumors. Despite decades of research, there has been minimal improvement in treatment and the clinical prognosis remains poor. Autophagy, a highly conserved process for recycling metabolic substrates is upregulated in pHGG, promoting tumor progression and evading cell death. There is significant crosstalk between autophagy and a plethora of critical cellular pathways, many of which are dysregulated in pHGG. The following article will discuss our current understanding of autophagy signaling in pHGG and the potential modulation of this network as a therapeutic target.
ISSN:1015-6305
1750-3639
DOI:10.1111/bpa.12729