Hypoglycemia during the Concomitant Use of Repaglinide and Clopidogrel in an Elderly Patient with Type 2 Diabetes and Severe Renal Insufficiency

Hypoglycemia should be avoided when treating patients with diabetes. Repaglinide is an insulin secretagogue with a low hypoglycemic risk because of its rapid- and short-acting effects. However, its blood concentration has been reported to increase in combination with clopidogrel, an antiplatelet dru...

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Bibliographic Details
Published in:Internal Medicine 2021/03/15, Vol.60(6), pp.905-910
Main Authors: Takayama, Kana, Fujii, Kohei, Yamaguchi, Hiroki, Miyoshi, Yumika, Uehara, Yuhei, Nagata, Shimpei, Obata, Yoshinari, Kosugi, Motohiro, Hazama, Yoji, Yasuda, Tetsuyuki
Format: Article
Language:English
Subjects:
Aged
Blood Glucose
Blood levels
Carbamates
Case Report
Clopidogrel
Clopidogrel - adverse effects
cytochrome P450 2C8
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - drug therapy
Humans
Hypoglycemia
Hypoglycemia - chemically induced
Hypoglycemia - drug therapy
Hypoglycemic Agents - adverse effects
Insulin
Internal medicine
Kidneys
Patients
Piperidines
Renal insufficiency
Renal Insufficiency - chemically induced
Renal Insufficiency - complications
repaglinide
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Summary:Hypoglycemia should be avoided when treating patients with diabetes. Repaglinide is an insulin secretagogue with a low hypoglycemic risk because of its rapid- and short-acting effects. However, its blood concentration has been reported to increase in combination with clopidogrel, an antiplatelet drug, and in patients with severe renal insufficiency. We herein report an elderly patient with type 2 diabetes mellitus and severe renal insufficiency who received repaglinide and hypoglycemia three days after starting clopidogrel. The concomitant use of repaglinide and clopidogrel can lead to hypoglycemia, especially in patients with severe renal insufficiency.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.5578-20