Severe acute respiratory syndrome coronavirus 2 ORF3a induces the expression of ACE2 in oral and pulmonary epithelial cells and the food supplement Vita Deyun ® diminishes this effect

The coronavirus disease 2019 (COVID-19) pandemic has become a serious global health problem and numerous studies are currently being conducted to improve understanding of the components of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, as well as to identify solutions that m...

Full description

Saved in:
Bibliographic Details
Published in:Experimental and therapeutic medicine 2021-05, Vol.21 (5), p.485-485, Article 485
Main Authors: Aguilar-Lemarroy, Adriana, López-Uribe, Apolinar, Sánchez-Corona, José, Jave-Suárez, Luis Felipe
Format: Article
Language:English
Subjects:
Angiotensin converting enzyme
Antigens
Cell culture
Coronaviruses
COVID-19
Cytokines
Diabetes
Dietary supplements
Disease transmission
Health aspects
Hypertension
Immune system
Infections
Lungs
Open reading frames
Pandemics
Physiological aspects
Proteins
Respiratory diseases
Selenium
Severe acute respiratory syndrome coronavirus 2
Viral infections
Vitamin C
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The coronavirus disease 2019 (COVID-19) pandemic has become a serious global health problem and numerous studies are currently being conducted to improve understanding of the components of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, as well as to identify solutions that mitigate the effects of COVID-19 symptoms. The nutritional supplement Vita Deyun is composed of silymarin, glutathione, vitamin C and selenium. Studies of its individual components have demonstrated their benefits as anti-inflammatory agents, antioxidants and enhancers of the immune response. Therefore, the present study aimed to evaluate the effects of Vita Deyun on the expression of angiotensin-converting enzyme 2 ( ) in diverse cell lines, as well as in the presence or absence of the SARS-CoV-2 open reading frame (ORF)3a protein. Through reverse transcription-quantitative PCR, the use of viral particles containing SARS-CoV-2 ORF3a and bioinformatics analysis via the National Center for Biotechnology Information databases, was determined to be highly expressed in oral and skin epithelial cells, with a lower expression observed in lung cells. Notably, the expression of SARS-CoV-2 ORF3a increased the level of expression and Vita Deyun treatment diminished this effect. In addition, Vita Deyun treatment markedly decreased interleukin-18 mRNA levels. The combination of phytonutrients in Vita Deyun may help to boost the immune system and could reduce the effects of COVID-19. Ongoing clinical studies are required to provide evidence of the efficacy of Vita Deyun.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2021.9916