Globe salvage treatment in group D and group E retinoblastoma

Globe salvage marks the treatment success of retinoblastoma. To evaluate four treatment strategies in group D and group E retinoblastoma. Retrospective case series in a tertiary hospital. 81 patients with Group D and Group E retinoblastoma. Participants were divided into four sets. In set I, eyes re...

Full description

Saved in:
Bibliographic Details
Published in:Romanian journal of ophthalmology 2021-01, Vol.65 (1), p.20-24
Main Authors: Hussain, Ahmad Khaqan, Rahul, Rachwani Anil, Carlos, Rocha de Lossada, Francisco, Zamorano Martín, María, García Lorente, Flavia, Pennisi, Chiara, Bonzano, Davide, Borroni
Format: Article
Language:English
Subjects:
Adult
Combined Modality Therapy
Cryotherapy - methods
Eye Enucleation - methods
Female
Follow-Up Studies
Humans
Infusions, Intravenous
Male
Melphalan - administration & dosage
Myeloablative Agonists - administration & dosage
Neoplasm Staging
Retinal Neoplasms - diagnosis
Retinal Neoplasms - therapy
Retinoblastoma - diagnosis
Retinoblastoma - therapy
Retrospective Studies
Salvage Therapy - methods
Treatment Outcome
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Globe salvage marks the treatment success of retinoblastoma. To evaluate four treatment strategies in group D and group E retinoblastoma. Retrospective case series in a tertiary hospital. 81 patients with Group D and Group E retinoblastoma. Participants were divided into four sets. In set I, eyes received primary intravenous chemotherapy (IVC), cryotherapy (CT), laser therapy (LT) and Intravitreal Chemotherapy with Melphalan (IViC). In set II, primary IVC was combined with second line IVC, CT, LT and IVT-M. Set III eyes received primary IVC and Intra-arterial chemotherapy (IAC), CT, LT and IViC. Set IV eyes received IAC, CT, LT and IViC. Treatment failure was defined as inadequate response during or after IVC or IAC. globe salvage and enucleation rates. 52 eyes were included in group D and 29 in group E. In group D, globe salvage was obtained in 8 out of 11 eyes in Set I, 13 out of 19 eyes in set II, 5 out 6 eyes in set III, and 13 out of 16 eyes in set IV. In group E, enucleation was performed in 17 eyes. Global salvage was obtained in 0 out of 2 eyes in set I, 2 out of 3 eyes in set II, 3 out of 5 in set III, and in 1 out of 2 eyes in set IV. IVC with adjuvant IAC, LT, CT and IViC has shown favorable results as a treatment method for group D and group E retinoblastoma.
ISSN:2457-4325
2501-2533
DOI:10.22336/rjo.2021.5