The Influence of Gliomas and Nonglial Space-occupying Lesions on Blood-oxygen-level-dependent Contrast Enhancement

Functional MR (fMR) imaging with blood-oxygen-level-dependent (BOLD) contrast enhancement is increasingly used as a noninvasive tool for presurgical mapping in patients with intracranial tumors. Most physiologic studies of task-related BOLD contrast enhancement have involved healthy volunteers. Ther...

Full description

Saved in:
Bibliographic Details
Published in:American journal of neuroradiology : AJNR 2000-06, Vol.21 (6), p.1055-1063
Main Authors: Schreiber, Axel, Hubbe, Ulrich, Ziyeh, Sargon, Hennig, Jurgen
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain
Brain Diseases - blood
Brain Diseases - physiopathology
Brain Neoplasms - blood
Brain Neoplasms - physiopathology
Cerebrovascular Circulation
Contrast Media
Glioma - blood
Glioma - physiopathology
Hand - physiopathology
Humans
Magnetic Resonance Imaging
Medical sciences
Motor Activity - physiology
Motor Cortex - blood supply
Motor Cortex - physiopathology
Neurology
Oxygen - blood
Somatosensory Cortex - blood supply
Somatosensory Cortex - physiopathology
Tumors of the nervous system. Phacomatoses
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Functional MR (fMR) imaging with blood-oxygen-level-dependent (BOLD) contrast enhancement is increasingly used as a noninvasive tool for presurgical mapping in patients with intracranial tumors. Most physiologic studies of task-related BOLD contrast enhancement have involved healthy volunteers. Therefore, it is not known whether BOLD contrast is evoked in the same way in or adjacent to tumor tissue. The purpose of this study was to study the influence of different intracranial tumors on BOLD contrast enhancement. fMR mapping of the sensorimotor cortex was successfully performed in 15 of 21 patients with intracranial space-occupying lesions by using a bimanual motor task. Tumors were located either within the sensorimotor area itself or in adjacent brain areas, inducing changes of signal intensity on T2-weighted images along the pre- or postcentral gyrus. Space-occupying lesions were divided into a group comprising gliomas (seven cases) and a group comprising nonglial space-occupying lesions (three metastases, two cavernomas, one abscess, one arteriovenous malformation, one meningioma). A hemispheric activation index was calculated using the volume of activation on the affected and on the contralateral hemisphere. Hemispheric activation indices of gliomas and nonglial lesions were compared statistically. The activated volume in the hemispheres ipsilateral to the nonglial lesions was 14% larger than in the contralateral hemisphere, whereas in the hemispheres ipsilateral to gliomas, the activated volume decreased by 36% in comparison with the contralateral hemisphere. The difference between nonglial lesions and gliomas was significant (P < .05). The generation of BOLD contrast enhancement is reduced near gliomas but is not affected by nonglial tumors.
ISSN:0195-6108
1936-959X