Constrained Source Space MR Spectroscopy: Multiple Voxels, No Gradient Readout

Our goal was to develop a novel technique for measuring a small number of localized spectra simultaneously and in a time-efficient manner. Using appropriate radiofrequency pulses, the magnetization from multiple voxels is excited simultaneously and then separated (reconstructed) by using the individ...

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Bibliographic Details
Published in:American journal of neuroradiology : AJNR 2015-08, Vol.36 (8), p.1436-1443
Main Authors: Landheer, K, Sahgal, A, Das, S, Graham, S J
Format: Article
Language:English
Subjects:
Adult
Adult Brain
Aged
Brain Mapping - methods
Brain Neoplasms - diagnosis
Female
Humans
Image Processing, Computer-Assisted - methods
Magnetic Resonance Spectroscopy - methods
Male
Middle Aged
Sensitivity and Specificity
Signal-To-Noise Ratio
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Summary:Our goal was to develop a novel technique for measuring a small number of localized spectra simultaneously and in a time-efficient manner. Using appropriate radiofrequency pulses, the magnetization from multiple voxels is excited simultaneously and then separated (reconstructed) by using the individual coil-sensitivity profiles from a multichannel receiver coil. Because no gradients are used for k-space encoding, constrained source space MR spectroscopy provides a time advantage over conventional spectroscopic imaging and an improved signal-to-noise ratio per square root of unit time over single-voxel spectroscopy applied at each successive location. In the present work, we considered prototype application of constrained source space MR spectroscopy for 2 voxels. Experimental data from healthy volunteers and simulation results showed that constrained source space MR spectroscopy is effective at extracting 2 independent spectra even in the challenging scenario of the voxels being closely spaced. Also, from 6 patients with various types of brain cancer we obtained 2-voxel constrained source space MR spectroscopy data, which showed spectra of clinical quality in half the time required to perform successive single-voxel MR spectroscopy. Constrained source space MR spectroscopy provides clinical quality spectra and could be used to probe multiple voxels simultaneously in combination with Hadamard encoding for further scan-time reductions.
ISSN:0195-6108
1936-959X
DOI:10.3174/ajnr.A4319