Deterioration in right ventricular structure and function over time in patients with heart failure and preserved ejection fraction

Abstract Aims Prevalent right ventricular (RV) dysfunction (RVD) is associated with increased mortality in patients with heart failure with preserved ejection fraction (HFpEF), but no study has characterized long-term changes in RV structure and function within the same patient. Methods and results...

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Bibliographic Details
Published in:European heart journal 2019-02, Vol.40 (8), p.689-697
Main Authors: Obokata, Masaru, Reddy, Yogesh N V, Melenovsky, Vojtech, Pislaru, Sorin, Borlaug, Barry A
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Atrial Fibrillation - complications
Clinical Research
Echocardiography
Editor's Choice
Female
Heart Failure - complications
Heart Failure - mortality
Heart Failure - pathology
Heart Failure - physiopathology
Heart Ventricles - diagnostic imaging
Heart Ventricles - pathology
Hemodynamics
Hospitalization
Humans
Logistic Models
Male
Middle Aged
Retrospective Studies
Stroke Volume
Tricuspid Valve Insufficiency - etiology
Ventricular Dysfunction, Right
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Summary:Abstract Aims Prevalent right ventricular (RV) dysfunction (RVD) is associated with increased mortality in patients with heart failure with preserved ejection fraction (HFpEF), but no study has characterized long-term changes in RV structure and function within the same patient. Methods and results Patients with unequivocal HFpEF defined by either invasive haemodynamics or hospitalization for pulmonary oedema (n = 271) underwent serial echocardiographic evaluations >6 months apart. Clinical, structural, functional, and haemodynamic characteristics were examined. Over a median of 4.0 years (interquartile range 2.1–6.1), there was a 10% decline in RV fractional area change and 21% increase in RV diastolic area (both P 
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehy809