Deletion of the RGD motif in LON-2/glypican is associated with morphological abnormalities
The gene in encodes a heparan sulfate proteoglycan family glypican that negatively regulates the BMP signaling pathway responsible for controlling body length. LON-2 contains multiple functional domains, including an RGD (Arg-Gly-Asp) motif at amino acid number from 348 to 350. A novel mutant allele...
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| Published in: | microPublication biology 2021-03, Vol.2021 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | eng |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | The
gene in
encodes a heparan sulfate proteoglycan family glypican that negatively regulates the BMP signaling pathway responsible for controlling body length. LON-2 contains multiple functional domains, including an RGD (Arg-Gly-Asp) motif at amino acid number from 348 to 350. A novel mutant allele of
was investigated in this study. In this mutant allele,
, the RGD motif at position 348 was deleted. Another pre-existing mutant allele,
, contains a ~9kb deletion and lacks most of the genomic coding sequence. The
line was used as a reference allele. The novel mutant line was significantly shorter than wild-type animals, suggesting that removal of the RGD motif in LON-2 may improve its ability to inhibit BMP signaling. |
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| ISSN: | 2578-9430 |