No Evidence of rVSV-Ebola Virus Vaccine Replication or Dissemination in the Sand Fly Phlebotomus papatasi

Following vaccination with the live attenuated, recombinant vesicular stomatitis virus Indiana serotype Ebola virus (rVSV-EBOV) vaccine, persons may exhibit a transient vaccine-associated viremia. To investigate the potential for Old World sand flies to transmit this vaccine following feeding on a v...

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Bibliographic Details
Published in:The American journal of tropical medicine and hygiene 2021-03, Vol.104 (3), p.1093-1095
Main Authors: Haddow, Andrew D, Rowland, Tobin E, Norris, Sarah L, Sprague, Thomas R, Lopez, Jorge O, Carder, Mark C, Linton, Yvonne-Marie, Pitt, M Louise M
Format: Article
Language:English
Subjects:
Animals
Antibodies, Viral - blood
Disease transmission
Disease Transmission, Infectious
Ebola Vaccines - immunology
Ebola virus
Ebolavirus - drug effects
Hemorrhagic Fever, Ebola - prevention & control
Hemorrhagic Fever, Ebola - transmission
Humans
Immunization
Insects
Phlebotomus - virology
Vaccines
Virology
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Summary:Following vaccination with the live attenuated, recombinant vesicular stomatitis virus Indiana serotype Ebola virus (rVSV-EBOV) vaccine, persons may exhibit a transient vaccine-associated viremia. To investigate the potential for Old World sand flies to transmit this vaccine following feeding on a viremic person, we fed laboratory-reared Phlebotomus papatasi an artificial blood meal containing 7.2 log10 plaque-forming units of rVSV-EBOV. Replication or dissemination was not detected in the body or legs of any P. papatasi collected at seven (n = 75) or 15 (n = 75) days post-feed. These results indicate a low potential for rVSV-EBOV to replicate and disseminate in P. papatasi, a species whose geographic distribution ranges from Morocco to southwest Asia and as far north as southern Europe.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.20-0951