Autophagosome maturation stymied by SARS-CoV-2

Many pathogens are capable of disrupting autophagy within host cells. In this issue of Developmental Cell, Miao et al. discover that the SARS-CoV-2 protein ORF3a inhibits autophagosome-lysosome fusion by dysregulating the HOPS complex. Many pathogens are capable of disrupting autophagy within host c...

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Bibliographic Details
Published in:Developmental cell 2021-02, Vol.56 (4), p.400-402
Main Authors: Yim, Willa Wen-You, Mizushima, Noboru
Format: Article
Language:English
Subjects:
Autophagosomes
Autophagy
COVID-19
Humans
Lysosomes
Membrane Fusion
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SARS-CoV-2
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Summary:Many pathogens are capable of disrupting autophagy within host cells. In this issue of Developmental Cell, Miao et al. discover that the SARS-CoV-2 protein ORF3a inhibits autophagosome-lysosome fusion by dysregulating the HOPS complex. Many pathogens are capable of disrupting autophagy within host cells. In this issue of Developmental Cell, Miao et al. discover that the SARS-CoV-2 protein ORF3a inhibits autophagosome-lysosome fusion by dysregulating the HOPS complex.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2021.02.002