Tumor Growth Suppression With Novel Intra-arterial Chemotherapy Using Epirubicin-entrapped Water-in-oil-in-water Emulsion In Vivo

A mixture of anticancer agents and iodized poppy seed oil (IPSO) has been widely used for intra-arterial chemotherapy of hepatocellular carcinoma. However, the anticancer agents can easily separate from IPSO, so the therapeutic potential is limited. We developed epirubicin-entrapped water-in-oil-in-...

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Bibliographic Details
Published in:In vivo (Athens) 2021-01, Vol.35 (1), p.239-248
Main Authors: Yanagie, Hironobu, Fujino, Takashi, Yanagawa, Masashi, Terao, Toshimitsu, Imagawa, Takashi, Fujihara, Mitsuteru, Morishita, Yasuyuki, Mizumachi, Ryouji, Murata, Yuuji, Dewi, Novriana, Ono, Yuuya, Ikushima, Ichiro, Seguchi, Koji, Nagata, Masashi, Nonaka, Yasumasa, Furuya, Yoshitaka, Hisa, Tomoyuki, Nagasaki, Takeshi, Arimori, Kazuhiko, Nakashima, Tadao, Sugihara, Takumichi, Kakimi, Kazuhiro, Ono, Minoru, Nakajima, Jun, Eriguchi, Masazumi, Higashi, Shushi, Takahashi, Hiroyuki
Format: Article
Language:English
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Summary:A mixture of anticancer agents and iodized poppy seed oil (IPSO) has been widely used for intra-arterial chemotherapy of hepatocellular carcinoma. However, the anticancer agents can easily separate from IPSO, so the therapeutic potential is limited. We developed epirubicin-entrapped water-in-oil-in-water emulsion (WOW-Epi) using a double-membrane emulsification technique. We delivered WOW-Epi through a hepatic arterial injection to VX2 hepatic tumor rabbit model (1.2 mg/kg). VX2 tumor growth was selectively suppressed in the WOW-Epi-treated group compared with the control treated groups. The accumulation of WOW in nearby cancer cells was confirmed via electron-microscopy. Endocytosis seemed to be the mechanism underlying the uptake of WOW. WOW-Epi led to tumour growth suppression in vivo. WOW does not cause toxicity to arterial vessels. WOW-Epi will be hopefully used for repeated intra-arterial chemotherapy to HCC patients in the near future.
ISSN:0258-851X
1791-7549
DOI:10.21873/invivo.12252