Anti-mitochondrial Antibodies in Patients with Dilated Cardiomyopathy

Objective It has been reported that anti-mitochondrial antibodies (AMAs) recognize mitochondrial antigens and are associated with some diseases involving multiple organs, such as primary biliary cholangitis, Sjögren syndrome, Hashimoto's thyroiditis, systemic sclerosis, interstitial pneumoniae,...

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Published in:	Internal Medicine 2021/01/15, Vol.60(2), pp.201-208
Main Authors:	Yokokawa, Tetsuro, Yoshihisa, Akiomi, Misaka, Tomofumi, Sato, Takamasa, Kaneshiro, Takashi, Oikawa, Masayoshi, Kobayashi, Atsushi, Yamaki, Takayoshi, Kunii, Hiroyuki, Takeishi, Yasuchika
Format:	Article
Language:	eng
Subjects:	Aged Alanine Alkaline phosphatase anti-mitochondrial antibodies Antibodies Antigens Aspartate transaminase Brain natriuretic peptide Cardiomyopathy Cardiomyopathy, Dilated - epidemiology Cholangitis Dilated cardiomyopathy Hashimoto's thyroiditis Heart Humans Liver Cirrhosis, Biliary Male Mitochondria Myopathy Natriuretic Peptide, Brain Nephritis Original primary biliary cholangitis Sjogren's syndrome Stroke Volume Systemic sclerosis Thyroiditis Transaminase Ventricle Ventricular Function, Left
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Summary:	Objective It has been reported that anti-mitochondrial antibodies (AMAs) recognize mitochondrial antigens and are associated with some diseases involving multiple organs, such as primary biliary cholangitis, Sjögren syndrome, Hashimoto's thyroiditis, systemic sclerosis, interstitial pneumoniae, dilated cardiomyopathy, and tubulointerstitial nephritis. In the current study, we examined the prevalence of AMAs in patients with dilated cardiomyopathy (DCM) and their clinical characteristics. Methods We enrolled 270 patients with DCM. We measured serum AMAs and analyzed the associated factors. Out of the 270 patients, positive AMAs were detected in 3 patients (1.1%; mean age, 68 years old; 2 men). These three patients had a significantly higher prevalence of primary biliary cholangitis and myopathy and levels of alanine alkaline phosphatase than those who were negative for said antibodies. There were no significant differences in the levels of B-type natriuretic peptide, aspartate transaminase, and left ventricular ejection fraction between these groups of patients. During the follow-up period, two of the three patients died due to respiratory failure. The other patient survived but experienced type II respiratory failure. Conclusion The prevalence of AMAs in 270 DCM patients was only 1.1%, and these patients suffered from respiratory failure.
ISSN:	0918-2918 1349-7235