The Heated Relationship Between Neural Activity and Seizures

Interneuron Desynchronization Precedes Seizures in a Mouse Model of Dravet Syndrome Tran CH, Vaiana M, Nakuci J, et al. J Neurosci. 2020 Mar 25;40(13):2764-2775. doi: 10.1523/JNEUROSCI.2370-19.2020. Epub 2020 Feb 26. PMID: 32102923; PMCID: PMC7096149. Recurrent seizures, which define epilepsy, are t...

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Bibliographic Details
Published in:Epilepsy currents 2021-01, Vol.21 (1), p.62-63
Main Author: Weston, Matthew C.
Format: Article
Language:English
Subjects:
Body temperature
Calcium imaging
Convulsions & seizures
Current Literature in Basic Science
Epilepsy
Interneurons
Neocortex
Neurodevelopmental disorders
Neuroimaging
Parvalbumin
Seizures
Sleep and wakefulness
Sodium channels (voltage-gated)
Synchronization
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Summary:Interneuron Desynchronization Precedes Seizures in a Mouse Model of Dravet Syndrome Tran CH, Vaiana M, Nakuci J, et al. J Neurosci. 2020 Mar 25;40(13):2764-2775. doi: 10.1523/JNEUROSCI.2370-19.2020. Epub 2020 Feb 26. PMID: 32102923; PMCID: PMC7096149. Recurrent seizures, which define epilepsy, are transient abnormalities in the electrical activity of the brain. The mechanistic basis of seizure initiation, and the contribution of defined neuronal subtypes to seizure pathophysiology, remains poorly understood. We performed in vivo 2-photon calcium imaging in neocortex during temperature-induced seizures in male and female Dravet syndrome (Scn1a +/−) mice, a neurodevelopmental disorder with prominent temperature-sensitive epilepsy. Mean activity of both putative principal cells and parvalbumin-positive interneurons (PV-INs) was higher in Scn1a +/− relative to wild-type controls during quiet wakefulness at baseline and at elevated core body temperature. However, wild-type PV-INs showed a progressive synchronization in response to temperature elevation that was absent in PV-INs from Scn1a +/− mice. Hence, PV-IN activity remains intact interictally in Scn1a +/− mice, yet exhibits decreased synchrony immediately before seizure onset. We suggest that impaired PV-IN synchronization may contribute to the transition to the ictal state during temperature-induced seizures in Dravet syndrome.
ISSN:1535-7597
1535-7511
DOI:10.1177/1535759720976371