Impact of real-time angiographic co-registered optical coherence tomography on percutaneous coronary intervention: the OPTICO-integration II trial

Aims Longitudinal geographic mismatch (LGM) as well as edge dissections are associated with an increased risk of adverse events after percutaneous coronary intervention (PCI). Recently, a novel system of real-time optical coherence tomography (OCT) with angiographic co-registration (ACR) became avai...

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Published in:Clinical research in cardiology 2021-02, Vol.110 (2), p.249-257
Main Authors: Schneider, Vera S., Böhm, Felix, Blum, Katharina, Riedel, Matthias, Abdelwahed, Youssef S., Klotsche, Jens, Steiner, Julia K., Heuberger, Andrea, Skurk, Carsten, Mochmann, Hans-Christian, Lauten, Alexander, Fröhlich, Georg, Rauch-Kröhnert, Ursula, Haghikia, Arash, Sinning, David, Stähli, Barbara E., Landmesser, Ulf, Leistner, David M.
Format: Article
Language:English
Subjects:
Angiography
Angioplasty
Cardiology
Dissection
Integration
Medical imaging
Medicine
Medicine & Public Health
Optical Coherence Tomography
Original Paper
Real time
Tomography
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Summary:Aims Longitudinal geographic mismatch (LGM) as well as edge dissections are associated with an increased risk of adverse events after percutaneous coronary intervention (PCI). Recently, a novel system of real-time optical coherence tomography (OCT) with angiographic co-registration (ACR) became available and allows matched integration of cross-sectional OCT images to angiography. The OPTICO-integration II trial sought to assess the impact of ACR for PCI planning on the risk of LGM and edge dissections. Methods A total of 84 patients were prospectively randomized to ACR-guided PCI, OCT-guided PCI (without co-registration), and angiography-guided PCI. Primary endpoint was a composite of major edge dissection and/or LGM as assessed by post-PCI OCT. Results The primary endpoint was significantly reduced in ACR-guided PCI (4.2%) as compared to OCT-guided PCI (19.1%; p  = 0.03) and angiography-guided PCI (25.5%; p  
ISSN:1861-0684
1861-0692
DOI:10.1007/s00392-020-01739-1