Nasal-type extranodal NK/T-cell lymphoma: a diagnostic challenge

Correspondence to Dr Rita Gama; ritarocha@campus.ul.pt Description A 72-year-old man presented to the emergency department with a 3-week history of fatigue, weight loss, night sweats, fever and severe nasal obstruction with nasal discharge. CT scan images revealed a neoformative lesion occupying the...

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Bibliographic Details
Published in:BMJ case reports 2021-01, Vol.14 (1), p.e241500
Main Authors: Gama, Rita, Sousa, Manuel, Castro, Fernanda, Condé, Artur
Format: Article
Language:English
Subjects:
Aged
Biopsy
Case reports
Coronaviruses
COVID-19
Ears & hearing
Epstein-Barr virus
Fatal Outcome
Humans
Images In
Lymphoma
Lymphoma, Extranodal NK-T-Cell - diagnosis
Male
Medical diagnosis
Nasal Cavity - diagnostic imaging
Nasal Cavity - pathology
Nose
Pneumonia
Severe acute respiratory syndrome coronavirus 2
Skin - pathology
Tomography, X-Ray Computed
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Description
Summary:Correspondence to Dr Rita Gama; ritarocha@campus.ul.pt Description A 72-year-old man presented to the emergency department with a 3-week history of fatigue, weight loss, night sweats, fever and severe nasal obstruction with nasal discharge. CT scan images revealed a neoformative lesion occupying the anterior portion of the left nasal cavity with 1×1.4 cm, showing heterogeneous contrast uptake, and conditioning right septum deviation and total obliteration of the anterior left nasal cavity (figure 2). ENNKTL, nasal type, also known as lethal midline granuloma, is an Epstein-Barr virus-associated lymphoma, and represents about 0.44% of the extranodal sinonasal lymphomas.1 2 The nose is the most common initial involved site, and can manifest as an intranasal lesion conditioning obstructive symptoms, with bleeding and purulent nasal discharge.3 Commonly it manifests with unspecific symptoms of rhinitis or sinusitis, making a malignant diagnosis difficult to suspect.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2020-241500