PDCD1 and IFNL4 genetic variants and risk of developing hepatitis C virus‐related diseases

Background Genetic variants of IFNL4 and PDCD1 genes have been shown to influence the spontaneous clearance of hepatitis C virus (HCV) infection. We investigated the IFNL4 rs12979860 and the PDCD1 polymorphisms in 734 HCV‐positive patients, including 461 cases with liver disease of varying severity...

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Bibliographic Details
Published in:Liver international 2021-01, Vol.41 (1), p.133-149
Main Authors: De Re, Valli, Tornesello, Maria Lina, De Zorzi, Mariangela, Caggiari, Laura, Pezzuto, Francesca, Leone, Patrizia, Racanelli, Vito, Lauletta, Gianfranco, Zanussi, Stefania, Repetto, Ombretta, Gragnani, Laura, Rossi, Francesca Maria, Dolcetti, Riccardo, Zignego, Anna Linda, Buonaguro, Franco M., Steffan, Agostino
Format: Article
Language:English
Subjects:
Amino acids
Antigens
Blood
Blood donors
Carcinoma, Hepatocellular - genetics
Cases (containers)
CD19 antigen
CD4 antigen
cryoglobulinaemia
Epistasis
Flow cytometry
Gene expression
Genes
Genetic diversity
Genetic factors
Genetic variance
Genetics and Rare Liver Diseases
Genotypes
Haplotypes
Hepacivirus
Hepatitis
Hepatitis C
Hepatitis C, Chronic - complications
Hepatitis C, Chronic - genetics
hepatitis virus C
Hepatocellular carcinoma
Humans
IFNλ4
Immune clearance
Immunoglobulin M
Immunoproliferative diseases
Interleukins - genetics
Leukocytes, Mononuclear
Linkage disequilibrium
Liver diseases
Liver Neoplasms - genetics
Lymphocytes
Lymphocytes B
Lymphocytes T
mRNA
Original
Pathogenesis
PD-L1 protein
PD‐1
Peripheral blood mononuclear cells
Programmed Cell Death 1 Receptor - genetics
Viruses
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Summary:Background Genetic variants of IFNL4 and PDCD1 genes have been shown to influence the spontaneous clearance of hepatitis C virus (HCV) infection. We investigated the IFNL4 rs12979860 and the PDCD1 polymorphisms in 734 HCV‐positive patients, including 461 cases with liver disease of varying severity and 273 patients with lymphoproliferative disorders to determine the association of these genes with patient's outcome. Methods Expression levels of PDCD1 mRNA encoded by haplotypes were investigated by quantitative PCR in hepatocellular carcinoma (HCC) tissue and peripheral blood mononuclear cells. Flow cytometry was used to detect PD‐1 and its ligand PD‐L1. Results The frequency of IFNL4 rs12979860 C/T or T/T genotypes was significantly higher in patients with HCV‐related diseases than blood donors (P 
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.14667