Mannose binding lectin gene 2 (rs1800450) missense variant may contribute to development and severity of COVID-19 infection

COVID-19 followed a mortal course in some young patients without any underlying factors, however, it followed a very benign course in some very older individuals with multiple comorbidities. These observations question if some genetic factors may be related to the vulnerability and poor prognosis of...

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Published in:Infection, genetics and evolution genetics and evolution, 2021-04, Vol.89, p.104717-104717, Article 104717
Main Authors: Medetalibeyoglu, Alpay, Bahat, Gulistan, Senkal, Naci, Kose, Murat, Avci, Kader, Sayin, Gozde Yesil, Isoglu-Alkac, Ummuhan, Tukek, Tufan, Pehlivan, Sacide
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Case-Control Studies
Comorbidity
COVID-19
COVID-19 - genetics
COVID-19 - pathology
COVID-19 - virology
Cytokine
Female
Gene mutation
Genetic Predisposition to Disease
Humans
Hyperinflammation
Male
Mannose-Binding Lectin - genetics
Mannose-Binding Lectin - metabolism
MBL2
Middle Aged
Mutation, Missense
Protein Interaction Maps
Research Paper
SARS-CoV-2
SARS-CoV-2 - isolation & purification
Severity of Illness Index
Young Adult
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Summary:COVID-19 followed a mortal course in some young patients without any underlying factors, however, it followed a very benign course in some very older individuals with multiple comorbidities. These observations question if some genetic factors may be related to the vulnerability and poor prognosis of the disease. In this study, we aimed to investigate whether MBL2 gene B variant at codon 54 (rs1800450) were related to the variabilities in clinical course of this infection. 284 PCR-confirmed COVID-19 patients and 100 healthy controls were included in the study. COVID-19 patients were subdivided according to the clinical features and clinical characteristics were analyzed. DNAs of all patients and controls were examined for the codon 54 A/B (gly54asp: rs1800450) variation in exon 1 of the MBL2 gene. In univariate analysis, BB genotype of MBL2 gene was more common among COVID-19 cases compared with controls (10.9% vs 1.0%, respectively; OR = 12.1, 95%CI = 1.6–90.1, p = 0.001). Multivariate analyses, adjusted for age, sex and MBL genetic variants, revealed that when compared with the COVID-19 patients that had AA genotype (reference), the patients that had BB or AB genotypes suffered from a higher risk for severe disease (for BB genotype, odds ratio (OR) = 5.3, p 
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2021.104717