Impact of prior statin use on clinical outcomes in COVID-19 patients: data from tertiary referral hospitals during COVID-19 pandemic in Italy

Epidemiological evidence suggests that anti-inflammatory and immunomodulatory properties of statins may reduce the risk of infections and infection-related complications. We aimed to assess the impact of prior statin use on coronavirus disease (COVID-19) severity and mortality. In this observational...

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Published in:Journal of clinical lipidology 2021-01, Vol.15 (1), p.68-78
Main Authors: Mitacchione, Gianfranco, Schiavone, Marco, Curnis, Antonio, Arca, Marcello, Antinori, Spinello, Gasperetti, Alessio, Mascioli, Giosuè, Severino, Paolo, Sabato, Federica, Caracciolo, Maria M., Arabia, Gianmarco, D'Erasmo, Laura, Viecca, Maurizio, Mancone, Massimo, Galli, Massimo, Forleo, Giovanni B.
Format: Article
Language:English
Subjects:
Acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Adult
Aged
Coronavirus disease 2019 (COVID-19)
COVID-19 - mortality
COVID-19 - therapy
Disease-Free Survival
Female
Hospital Mortality
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects
In-hospital mortality
Male
Middle Aged
Original
SARS-CoV-2
Statin therapy
Survival Rate
Tertiary Care Centers
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Summary:Epidemiological evidence suggests that anti-inflammatory and immunomodulatory properties of statins may reduce the risk of infections and infection-related complications. We aimed to assess the impact of prior statin use on coronavirus disease (COVID-19) severity and mortality. In this observational multicenter study, consecutive patients hospitalized for COVID-19 were enrolled. In-hospital mortality and severity of COVID-19 assessed with National Early Warning Score (NEWS) were deemed primary and secondary outcomes, respectively. Propensity score (PS) matching was used to obtain balanced cohorts. Among 842 patients enrolled, 179 (21%) were treated with statins before admission. Statin patients showed more comorbidities and more severe COVID-19 (NEWS 4 [IQR 2–6] vs 3 [IQR 2–5], p 
ISSN:1933-2874
1876-4789
1933-2874
DOI:10.1016/j.jacl.2020.12.008