Clinical and pathological characteristics of peripheral T‐cell lymphomas in a Spanish population: a retrospective study

We investigated the clinicopathological features and prognostic factors of patients with peripheral T‐cell lymphoma (PTCL) in 13 sites across Spain. Relevant clinical antecedents, CD30 expression and staining pattern, prognostic indices using the International Prognostic Index and the Intergruppo It...

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Bibliographic Details
Published in:British journal of haematology 2021-01, Vol.192 (1), p.82-99
Main Authors: Rodriguez‐Pinilla, Socorro Maria, Domingo‐Domenech, Eva, Climent, Fina, Sanchez, Joaquin, Perez Seoane, Carlos, Lopez Jimenez, Javier, Garcia‐Cosio, Monica, Caballero, Dolores, Blanco Muñez, Oscar Javier, Carpio, Cecilia, Castellvi, Josep, Martinez Pozo, Antonio, Gonzalez Farre, Blanca, Bendaña, Angeles, Aliste, Carlos, Gonzalez, Ana Julia, Gonzalez de Villambrosia, Sonia, Piris, Miguel A., Gomez Codina, Jose, Mayordomo‐Aranda, Empar, Navarro, Belen, Bellas, Carmen, Rodriguez, Guillermo, Borrero, Juan Jose, Ruiz‐Zorrilla, Ana, Grande, Marta, Montoto, Carmen, Cordoba, Raul
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
anaplastic large‐cell lymphoma
anaplastic lymphoma kinase
Carcinoma
CD30 antigen
complete response
Female
Haematological Malignancy ‐ Clinical
Hematology
Humans
Ki-1 Antigen - analysis
Kinases
Lymphoma
Lymphoma, T-Cell, Peripheral - diagnosis
Lymphoma, T-Cell, Peripheral - epidemiology
Lymphoma, T-Cell, Peripheral - pathology
Male
Medical prognosis
Middle Aged
Natural killer cells
overall survival
Patients
peripheral T‐cell lymphoma
Population studies
Prognosis
progression‐free survival
Protein-tyrosine kinase
Radiation therapy
Research Paper
Retrospective Studies
Spain - epidemiology
Survival Analysis
T-cell lymphoma
Young Adult
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Summary:We investigated the clinicopathological features and prognostic factors of patients with peripheral T‐cell lymphoma (PTCL) in 13 sites across Spain. Relevant clinical antecedents, CD30 expression and staining pattern, prognostic indices using the International Prognostic Index and the Intergruppo Italiano Linfomi system, treatments, and clinical outcomes were examined. A sizeable proportion of 175 patients had a history of immune‐related disorders (autoimmune 16%, viral infections 17%, chemo/radiotherapy‐treated carcinomas 19%). The median progression‐free survival (PFS) and overall survival (OS) were 7·9 and 15·8 months, respectively. Prognostic indices influenced PFS and OS, with a higher number of adverse factors resulting in shorter survival (P 
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.16741