Serum levels of microRNA-371a-3p are not elevated in testicular tumours of non-germ cell origin

Purpose Serum levels of microRNA-371a-3p (M371) have been shown to be a highly sensitive and specific biomarker for testicular germ cell tumours (TGCT). Little information exists on the expression of this marker in testicular neoplasms deriving from the gonadal stroma or other structures of the gona...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2021-02, Vol.147 (2), p.435-443
Main Authors: Belge, Gazanfer, Grobelny, Francesca, Radtke, Arlo, Bodes, Jacqueline, Matthies, Cord, Wülfing, Christian, Dieckmann, Klaus-Peter
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biomarkers
Biomarkers, Tumor - blood
Cancer Research
Hematology
Humans
Internal Medicine
Lymphoma
Lymphoma - blood
Lymphoma - genetics
Male
Medicine
Medicine & Public Health
MicroRNAs
MicroRNAs - blood
Middle Aged
miRNA
Neoplasms, Germ Cell and Embryonal - blood
Neoplasms, Germ Cell and Embryonal - genetics
Oncology
Original Article – Cancer Research
Original – Cancer Research
Serum levels
Stroma
Surgery
Testes
Testicular cancer
Testicular Neoplasms - blood
Testicular Neoplasms - genetics
Tumors
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose Serum levels of microRNA-371a-3p (M371) have been shown to be a highly sensitive and specific biomarker for testicular germ cell tumours (TGCT). Little information exists on the expression of this marker in testicular neoplasms deriving from the gonadal stroma or other structures of the gonad. This study presents an expression analysis of the novel TGCT-biomarker M371 in a large cohort of testicular non-germ cell tumours. Methods The M371 expression was measured by quantitative real time PCR in serum of 99 patients with testicular tumours of non-germ cell origin, thereof 30 patients with malignant testicular lymphomas and 61 patients with gonadal stroma tumours such as Leydig cell tumours, Sertoli cell tumours and 8 cases with miscellaneous benign testicular tumours. Their M371 levels were compared to those of 20 patients with TGCT and to 37 tumour-free male controls. Results The median expression levels of benign testicular tumours and testicular lymphoma are close to zero, thus, identical with those of controls and significantly lower than those of TGCT. In summary, this study provides further evidence for the notion that M371 is exclusively expressed by germ cell tumours and not by testicular neoplasms of the non-germ cell subtypes. Conclusion Clinically, the test might be of value in preoperative characterization of benign testicular tumours eligible for conservative surgery.
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-020-03429-x