Maternal GABAergic and GnRH/corazonin pathway modulates egg diapause phenotype of the silkworm Bombyx mori

Diapause represents a major developmental switch in insects and is a seasonal adaptation that evolved as a specific subtype of dormancy in most insect species to ensure survival under unfavorable environmental conditions and synchronize populations. However, the hierarchical relationship of the mole...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2021-01, Vol.118 (1), p.1
Main Authors: Tsuchiya, Ryoma, Kaneshima, Aino, Kobayashi, Masakazu, Yamazaki, Maki, Takasu, Yoko, Sezutsu, Hideki, Tanaka, Yoshiaki, Mizoguchi, Akira, Shiomi, Kunihiro
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Biological Sciences
Bombyx - embryology
Bombyx - genetics
Bombyx - metabolism
Bombyx mori
Cell Membrane - metabolism
Corazonin protein
Diapause
Diapause - genetics
Diapause induction
Dormancy
Embryogenesis
Embryonic Development - genetics
Embryonic growth stage
Environmental conditions
GABA Plasma Membrane Transport Proteins - genetics
GABA Plasma Membrane Transport Proteins - metabolism
GABA-A Receptor Antagonists - pharmacology
GABAergic Neurons - drug effects
GABAergic Neurons - metabolism
gamma-Aminobutyric Acid - metabolism
Gonadotropin-releasing hormone
Gonadotropins
Hormone release
Insect Proteins - genetics
Insect Proteins - metabolism
Insects
Molecular modelling
Neuropeptides - genetics
Neuropeptides - metabolism
Offspring
Ovum - drug effects
Ovum - metabolism
Phenotypes
Phylogeny
Pituitary (anterior)
Progeny
Receptors, GABA-A - metabolism
Signal transduction
Signal Transduction - genetics
Signal Transduction - physiology
Signalling systems
Silkworms
Temperature dependence
Vertebrates
γ-Aminobutyric acid
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Summary:Diapause represents a major developmental switch in insects and is a seasonal adaptation that evolved as a specific subtype of dormancy in most insect species to ensure survival under unfavorable environmental conditions and synchronize populations. However, the hierarchical relationship of the molecular mechanisms involved in the perception of environmental signals to integration in morphological, physiological, behavioral, and reproductive responses remains unclear. In the bivoltine strain of the silkworm , embryonic diapause is induced transgenerationally as a maternal effect. Progeny diapause is determined by the environmental temperature during embryonic development of the mother. Here, we show that the hierarchical pathway consists of a γ-aminobutyric acid (GABA)ergic and corazonin signaling system modulating progeny diapause induction via diapause hormone release, which may be finely tuned by the temperature-dependent expression of plasma membrane GABA transporter. Furthermore, this signaling pathway possesses similar features to the gonadotropin-releasing hormone (GnRH) signaling system for seasonal reproductive plasticity in vertebrates.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.2020028118