Significant Association of MMP2 Promoter Genotypes to Asthma Susceptibility in Taiwan

Matrix metalloproteinase 2 (MMP2) is reported to be overexpressed in asthma; however, its genotypic contribution to asthma is not well studied. Therefore, we examined the association of MMP2 genotypes with asthma risk among Taiwanese. One hundred and ninety-eight asthma patients and 453 non-asthmati...

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Bibliographic Details
Published in:In vivo (Athens) 2020-11, Vol.34 (6), p.3181-3186
Main Authors: Chen, Li-Hsiou, Chiu, Kuo-Liang, Hsia, Te-Chun, Lee, Yen-Hsien, Shen, Te-Chun, Li, Chia-Hsiang, Shen, Yi-Cheng, Chang, Wen-Shin, Tsai, Chia-Wen, Bau, DA-Tian
Format: Article
Language:English
Subjects:
Asthma - epidemiology
Asthma - genetics
Case-Control Studies
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Matrix Metalloproteinase 2 - genetics
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Taiwan - epidemiology
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Summary:Matrix metalloproteinase 2 (MMP2) is reported to be overexpressed in asthma; however, its genotypic contribution to asthma is not well studied. Therefore, we examined the association of MMP2 genotypes with asthma risk among Taiwanese. One hundred and ninety-eight asthma patients and 453 non-asthmatic subjects were determined with respect to their MMP2 -1306 (rs243845) and -735 (rs2285053) genotypes. CT and TT at MMP2 rs243845 are 17.7% and 1.5% among asthma cases, whereas their presence in healthy subjects is at 28.1% and 2.4%, respectively (p for trend=0.0118). In detail, the CT genotype in MMP2 rs243845 was associated with a decreased asthma risk [adjusted odds ratio (OR)=0.57, 95% confidence interval (CI)=0.37-0.78, p=0.0040], and the T allele conferred a significantly lower asthma risk compared to the wild-type C allele (adjusted OR=0.55, 95%CI=0.43-0.77, p=0.0042). No significance was found for MMP2 rs2285053. The genotype of CT in MMP2 rs243845 may serve as a novel biomarker in determining susceptibility to asthma in Taiwan.
ISSN:0258-851X
1791-7549
DOI:10.21873/invivo.12153