Interleukin‐17 and ischaemic stroke

IL‐17 family was conducted with 6 members, most of them are widely involved in a variety of acute and chronic inflammatory responses, especially IL‐17A. After stroke, cerebral ischaemia and hypoxia lead nerve cell necrosis and release a large amount of damage‐associated molecular patterns and inflam...

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Bibliographic Details
Published in:Immunology 2021-02, Vol.162 (2), p.179-193
Main Authors: Zhang, Qiaohui, Liao, Yan, Liu, Zhenquan, Dai, Yajie, Li, Yunxin, Li, Yue, Tang, Yibo
Format: Article
Language:English
Subjects:
Animals
Arthritis
Autoimmune diseases
Autoimmune Diseases - immunology
Brain Ischemia - immunology
Cytokines
Humans
IL‐17A
Immune system
Inflammation
Inflammatory response
Interleukin-17 - immunology
Interleukins
interleukin‐17 (IL‐17)
Intracellular signalling
Ischemia
Ischemic Stroke - immunology
Multiple sclerosis
Physiological effects
Receptors, Interleukin-17 - immunology
Review
Rheumatoid arthritis
Signal transduction
Signal Transduction - immunology
Stroke
therapy
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Summary:IL‐17 family was conducted with 6 members, most of them are widely involved in a variety of acute and chronic inflammatory responses, especially IL‐17A. After stroke, cerebral ischaemia and hypoxia lead nerve cell necrosis and release a large amount of damage‐associated molecular patterns and inflammation factors to activate IL‐17A. Then, IL‐17A promotes the development of stroke by inducing the secretion of inflammatory factors (such as TNF‐α, IL‐6, CXCL1), recruiting neutrophils to infiltrate into central nervous system and impairing the integrity of blood–brain barrier. Summary Interleukin‐17 (IL‐17) is a cytokine family that includes 6 members, IL‐17A through IL‐17F, most of them are reported to have pro‐inflammatory role. Through binding to their receptors (IL‐17Rs), IL‐17 activates the intracellular signalling pathways to play an important role in autoimmune diseases, including rheumatoid arthritis (RA) and multiple sclerosis (MS). Ischaemic stroke is a complex pathophysiological process mainly caused by regional cerebral ischaemia. Inflammatory factors contribute to the physiological process of stroke that leads to poor prognosis. IL‐17 plays a crucial role in promoting inflammatory response and inducing secondary injury in post‐stroke. Though immune cells and inflammatory factors have been reported to be involved in the damage of stroke, the functions of IL‐17 in this process need to be elucidated. This review focuses on the pathological modulation and the mechanism of IL‐17 family in ischaemic stroke and seeking to provide new insights for future therapies.
ISSN:0019-2805
1365-2567
DOI:10.1111/imm.13265