Analysis of the Efficacy of Two Treatment Protocols for Patients with Symptomatic Oral Lichen Planus: A Randomized Clinical Trial

Oral lichen planus (OLP) is a chronic, inflammatory, immune-mediated disease, which can alter the quality of life of patients. The aim of this randomized clinical trial was to compare the therapeutic efficacy of clobetasol oral gel 0.05% versus an anti-inflammatory in oral solution (mouthwash) in th...

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Bibliographic Details
Published in:	International journal of environmental research and public health 2020-12, Vol.18 (1), p.56
Main Authors:	Santonocito, Simona, Polizzi, Alessandro, De Pasquale, Rocco, Ronsivalle, Vincenzo, Lo Giudice, Antonino, Isola, Gaetano
Format:	Article
Language:	eng
Subjects:	Administration, Topical Aged Anti-Inflammatory Agents - therapeutic use Clinical Protocols Clobetasol - therapeutic use Double-Blind Method Female Humans Lichen Planus, Oral - drug therapy Male Middle Aged Mouthwashes - therapeutic use Quality of Life
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Summary:	Oral lichen planus (OLP) is a chronic, inflammatory, immune-mediated disease, which can alter the quality of life of patients. The aim of this randomized clinical trial was to compare the therapeutic efficacy of clobetasol oral gel 0.05% versus an anti-inflammatory in oral solution (mouthwash) in the management of patients suffering from symptomatic OLP. The secondary objective was to analyze which one of the two treatments induced a greater risk of developing side effects. Forty patients were assigned (20 patients for group), through a randomized design, to receive clobetasol gel 0.05% or an anti-inflammatory mouthwash, which contains calcium hydroxide, hyaluronic acid, umbelliferone and oligomeric pro-anthocyanidins) for three months. At baseline (T0) and after 3 months (T1), patients underwent dental and dermatological examinations to assess their symptoms (Numerical Pain Scale (NRS) score) and signs (Thongprasom score). Data were calculated using -test for the dependent variable, Wilcoxon test and Mann-Whitney u test. Both clobetasol and anti-inflammatory resulted in a statistically significant reduction of signs, ( < 0.001 and = 0.02, respectively) and symptoms ( < 0.001 for clobetasol and = 0.02 for anti-inflammatory). In conclusion, the results evidenced that, compared to clobetasol, the anti-inflammatory was less effective in determining the reduction of signs and symptom in OLP patients.
ISSN:	1660-4601 1661-7827 1660-4601