Role of therapeutic plasma exchange in acute liver failure due to yellow phosphorus poisoning

Background Therapeutic plasma exchange (TPE) has been utilized in various liver disorders. There is limited data on the efficacy of TPE in patients with acute liver failure (ALF). Methods Study group consisted of patients who underwent TPE for ALF due to yellow phosphorous poisoning (YPP) between 20...

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Bibliographic Details
Published in:Indian journal of gastroenterology 2020-12, Vol.39 (6), p.544-549
Main Authors: Varghese, Joy, Joshi, Vivek, Bollipalli, Madhan Kumar, Malleeswaran, Selvakumar, Patcha, Rajinikanth, Nair, Harikumar, Vij, Vivek, Sachan, Deepti, Subramanian, Pushkala, Jain, Mayank, Venkataraman, Jayanthi
Format: Article
Language:English
Subjects:
Adult
Ammonia
Female
Gastroenterology
Hepatology
Humans
Hypersensitivity - etiology
Hypotension - etiology
International Normalized Ratio
Liver Failure, Acute - chemically induced
Liver Failure, Acute - mortality
Liver Failure, Acute - therapy
Liver Transplantation
Male
Medicine
Medicine & Public Health
Original
Original Article
Phosphorus - poisoning
Plasma Exchange - adverse effects
Plasma Exchange - methods
Plasma Exchange - mortality
Survival Rate
Treatment Outcome
Young Adult
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Summary:Background Therapeutic plasma exchange (TPE) has been utilized in various liver disorders. There is limited data on the efficacy of TPE in patients with acute liver failure (ALF). Methods Study group consisted of patients who underwent TPE for ALF due to yellow phosphorous poisoning (YPP) between 2015 and 2019. Demographic data and biochemical parameters were recorded before and after TPE. Overall survival and transplant-free survival (based on King’s College Hospital Criteria [KCHC]) were analyzed. Results Forty-three patients underwent TPE for ALF due to YPP. Most of them were young males. Overall survival was 34 (79.06%). In our study population, 20 patients fulfilled KCHC (Group A) and 23 did not fulfill KCHC (Group B). Both the groups showed significant improvement in alanine aminotransferase, aspartate aminotransferase, and international normalized ratio (INR) after TPE ( p  
ISSN:0254-8860
0975-0711
DOI:10.1007/s12664-020-01095-y