ProThermDB: thermodynamic database for proteins and mutants revisited after 15 years

Abstract ProThermDB is an updated version of the thermodynamic database for proteins and mutants (ProTherm), which has ∼31 500 data on protein stability, an increase of 84% from the previous version. It contains several thermodynamic parameters such as melting temperature, free energy obtained with...

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Bibliographic Details
Published in:Nucleic acids research 2021-01, Vol.49 (D1), p.D420-D424
Main Authors: Nikam, Rahul, Kulandaisamy, A, Harini, K, Sharma, Divya, Gromiha, M Michael
Format: Article
Language:English
Subjects:
Database Issue
Databases, Protein
Information Storage and Retrieval
Mutant Proteins - chemistry
Proteins - chemistry
Statistics as Topic
Thermodynamics
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Summary:Abstract ProThermDB is an updated version of the thermodynamic database for proteins and mutants (ProTherm), which has ∼31 500 data on protein stability, an increase of 84% from the previous version. It contains several thermodynamic parameters such as melting temperature, free energy obtained with thermal and denaturant denaturation, enthalpy change and heat capacity change along with experimental methods and conditions, sequence, structure and literature information. Besides, the current version of the database includes about 120 000 thermodynamic data obtained for different organisms and cell lines, which are determined by recent high throughput proteomics techniques using whole-cell approaches. In addition, we provided a graphical interface for visualization of mutations at sequence and structure levels. ProThermDB is cross-linked with other relevant databases, PDB, UniProt, PubMed etc. It is freely available at https://web.iitm.ac.in/bioinfo2/prothermdb/index.html without any login requirements. It is implemented in Python, HTML and JavaScript, and supports the latest versions of major browsers, such as Firefox, Chrome and Safari.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkaa1035