Virus load and virus shedding of SARS-CoV-2 and their impact on patient outcomes

Understanding a virus shedding patterns in body fluids/secretions is important to determine the samples to be used for diagnosis and to formulate infection control measures. To investigate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding patterns and its risk factors. All la...

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Published in:World journal of clinical cases 2020-12, Vol.8 (24), p.6252-6263
Main Authors: Chen, Pei-Fen, Yu, Xia-Xia, Liu, Yi-Peng, Ren, Di, Shen, Min, Huang, Bing-Sheng, Gao, Jun-Ling, Huang, Zheng-Yang, Wu, Ming, Wang, Wei-Yan, Chen, Li, Shi, Xia, Wang, Zhao-Qing, Liu, Ying-Xia, Liu, Lei, Liu, Yong
Format: Article
Language:English
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Retrospective Study
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Summary:Understanding a virus shedding patterns in body fluids/secretions is important to determine the samples to be used for diagnosis and to formulate infection control measures. To investigate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding patterns and its risk factors. All laboratory-confirmed coronavirus disease 2019 patients with complete medical records admitted to the Shenzhen Third People's Hospital from January 28, 2020 to March 8, 2020 were included. Among 145 patients (54.5% males; median age, 46.1 years), three (2.1%) died. The bronco-alveolar lavage fluid (BALF) had the highest virus load compared with the other samples. The viral load peaked at admission (3.3 × 10 copies) and sharply decreased 10 d after admission. The viral load was associated with prolonged intensive care unit (ICU) duration. Patients in the ICU had significantly longer shedding time compared to those in the wards ( < 0.0001). Age > 60 years [hazard ratio (HR) = 0.6; 95% confidence interval (CI): 0.4-0.9] was an independent risk factor for SARS-CoV-2 shedding, while chloroquine (HR = 22.8; 95%CI: 2.3-224.6) was a protective factor. BALF had the highest SARS-CoV-2 load. Elderly patients had higher virus loads, which was associated with a prolonged ICU stay. Chloroquine was associated with shorter shedding duration and increased the chance of viral negativity.
ISSN:2307-8960
2307-8960
DOI:10.12998/wjcc.v8.i24.6252