Consensus recommendations for optimizing biomarker testing to identify and treat advanced EGFR- mutated non-small-cell lung cancer

The advent of personalized therapy for non-small-cell lung carcinoma (nsclc) has improved patient outcomes. Selection of appropriate targeted therapy for patients with nsclc now involves testing for multiple biomarkers, including . mutation status is required to optimally treat patients with nsclc,...

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Bibliographic Details
Published in:Current oncology (Toronto) 2020-12, Vol.27 (6), p.321-329
Main Authors: Cheema, P K, Gomes, M, Banerji, S, Joubert, P, Leighl, N B, Melosky, B, Sheffield, B S, Stockley, T, Ionescu, D N
Format: Article
Language:English
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Practice Guideline
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Summary:The advent of personalized therapy for non-small-cell lung carcinoma (nsclc) has improved patient outcomes. Selection of appropriate targeted therapy for patients with nsclc now involves testing for multiple biomarkers, including . mutation status is required to optimally treat patients with nsclc, and thus timely and accurate biomarker testing is necessary. However, in Canada, there are currently no standardized processes or methods in place to ensure consistent testing implementation. That lack creates challenges in ensuring that all appropriate biomarkers are tested for each patient and that the medical oncologist receives the results for making informed treatment decisions in a timely way. An expert multidisciplinary working group was convened to create consensus recommendations about biomarker testing in advanced nsclc in Canada, with a primary focus on testing. Recognizing that there are biomarkers beyond that require timely identification, the expert multidisciplinary working group considered testing in the broader context of integration into complex lung biomarker testing. Primarily, the panel of experts recommends that all patients with nonsquamous nsclc, regardless of stage, should undergo comprehensive reflex biomarker testing at diagnosis with targeted next-generation sequencing. The panel also considered the testing algorithm and the challenges associated with the pre-analytic, analytic, and post-analytic elements of testing. Strategies for funding testing by reducing silos of single biomarker testing for and for optimally implementing the recommendations presented here and educating oncology professionals about them are also discussed.
ISSN:1718-7729
1198-0052
1718-7729
DOI:10.3747/co.27.7297