Breast conservation therapy versus mastectomy in the surgical management of invasive lobular carcinoma measuring 4 cm or greater

The safety of breast conservation therapy (BCT) has not been demonstrated in large ILC tumors, potentially contributing to the higher mastectomy rates seen in ILC. We queried a prospectively maintained database to identify patients with ILC measuring ≥4 cm and evaluated difference in recurrence free...

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Bibliographic Details
Published in:The American journal of surgery 2021-01, Vol.221 (1), p.32-36
Main Authors: Abel, Mary Kathryn, Brabham, Case E., Guo, Ruby, Fahrner-Scott, Kelly, Wong, Jasmine, Alvarado, Michael, Ewing, Cheryl, Esserman, Laura J., Mukhtar, Rita A.
Format: Article
Language:English
Subjects:
Adult
Aged
Breast
Breast cancer
Breast conservation surgery
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Cancer therapies
Carcinoma, Lobular - pathology
Carcinoma, Lobular - surgery
Female
Humans
Invasive lobular carcinoma
Invasiveness
Large tumors
Mastectomy
Mastectomy, Segmental
Middle Aged
Radiation therapy
Recurrence-free survival
Retrospective Studies
Tumor Burden
Tumors
Womens health
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Summary:The safety of breast conservation therapy (BCT) has not been demonstrated in large ILC tumors, potentially contributing to the higher mastectomy rates seen in ILC. We queried a prospectively maintained database to identify patients with ILC measuring ≥4 cm and evaluated difference in recurrence free survival (RFS) between those treated with BCT versus mastectomy using a multivariate model. Of 180 patients, 30 (16.7%) underwent BCT and 150 (83.3%) underwent mastectomy. Patients undergoing mastectomy were younger (56.6 vs. 64.3 years, p = 0.003) and had larger tumors (7.2 vs. 5.4 cm, p 
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2020.05.038